Phytochemical and antinociceptive study of leaves of Tabernaemontana divaricata (L)

Shazid Md. Sharker; Samabesh Chakma; Ahmed Ayedur Rahman

Phytochemical and antinociceptive study of leaves of Tabernaemontana divaricata (L)

Shazid Md. Sharker, Samabesh Chakma, Ahmed Ayedur Rahman

Research output: Contribution to journal › Article › peer-review

Abstract

The crude ethanol extract of leaves of Tabernaemontana divaricata (L). (Apocynaceae) was screened for its preliminary antinociceptive activity. The extract produced significant writhing inhibition in acetic acid induced mice at the oral dose of 250 and 500 mg/kg body weight respectively (P<0.05, P<0.01) comparable to the standard drug diclofenac sodium at the dose of 25 mg/kg of body weight. The result tends to suggest the antinociceptive activity of the extract.

Original language	English
Pages (from-to)	245-247
Number of pages	3
Journal	Journal of Medicinal Plants Research
Volume	5
Issue number	2
Publication status	Published - 18 Jan 2011
Externally published	Yes

Keywords

Tabernaemontana divaricata
antinociceptive
writhing

Cite this

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abstract = "The crude ethanol extract of leaves of Tabernaemontana divaricata (L). (Apocynaceae) was screened for its preliminary antinociceptive activity. The extract produced significant writhing inhibition in acetic acid induced mice at the oral dose of 250 and 500 mg/kg body weight respectively (P<0.05, P<0.01) comparable to the standard drug diclofenac sodium at the dose of 25 mg/kg of body weight. The result tends to suggest the antinociceptive activity of the extract.",

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N2 - The crude ethanol extract of leaves of Tabernaemontana divaricata (L). (Apocynaceae) was screened for its preliminary antinociceptive activity. The extract produced significant writhing inhibition in acetic acid induced mice at the oral dose of 250 and 500 mg/kg body weight respectively (P<0.05, P<0.01) comparable to the standard drug diclofenac sodium at the dose of 25 mg/kg of body weight. The result tends to suggest the antinociceptive activity of the extract.

AB - The crude ethanol extract of leaves of Tabernaemontana divaricata (L). (Apocynaceae) was screened for its preliminary antinociceptive activity. The extract produced significant writhing inhibition in acetic acid induced mice at the oral dose of 250 and 500 mg/kg body weight respectively (P<0.05, P<0.01) comparable to the standard drug diclofenac sodium at the dose of 25 mg/kg of body weight. The result tends to suggest the antinociceptive activity of the extract.

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KW - writhing

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JF - Journal of Medicinal Plants Research

IS - 2

ER -

Phytochemical and antinociceptive study of leaves of Tabernaemontana divaricata (L)

Abstract

Keywords

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