Pineal region germinomas in childhood treatment considerations

Derek Jenkin*, Martin Berry, Helen Chan, Mark Greenberg, Bruce Hendrick, Harold Hoffman, Robin Humphreys, Marilyn Sonley, Sheila Weitzman

*Corresponding author for this work

    Research output: Contribution to journalArticlepeer-review

    78 Citations (Scopus)


    From 1967-1986, 21 children were treated for pineal germinoma, including 16 biopsy-proven, 2 biopsy non-diagnostic, and 3 metastatic unbiopsied (marker negative) patients. Ten of 18 (56%) biopsied patients underwent partial or sub-total tumor resection. Twenty patients were irradiated, 19 of whom are alive. No irradiated patient died of progressive germinoma, but two patients relapsed in the spinal cord and required treatment intensification for salvage. Long-term survivors have significant morbidity. Determination of the minimum effective treatment remains the chief therapeutic challenge.

    Original languageEnglish
    Pages (from-to)541-545
    Number of pages5
    JournalInternational Journal of Radiation Oncology, Biology, Physics
    Issue number3
    Publication statusPublished - 1990


    • Pineal germinoma
    • radiation treatment


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