TY - JOUR
T1 - Pineal region germinomas in childhood treatment considerations
AU - Jenkin, Derek
AU - Berry, Martin
AU - Chan, Helen
AU - Greenberg, Mark
AU - Hendrick, Bruce
AU - Hoffman, Harold
AU - Humphreys, Robin
AU - Sonley, Marilyn
AU - Weitzman, Sheila
PY - 1990
Y1 - 1990
N2 - From 1967-1986, 21 children were treated for pineal germinoma, including 16 biopsy-proven, 2 biopsy non-diagnostic, and 3 metastatic unbiopsied (marker negative) patients. Ten of 18 (56%) biopsied patients underwent partial or sub-total tumor resection. Twenty patients were irradiated, 19 of whom are alive. No irradiated patient died of progressive germinoma, but two patients relapsed in the spinal cord and required treatment intensification for salvage. Long-term survivors have significant morbidity. Determination of the minimum effective treatment remains the chief therapeutic challenge.
AB - From 1967-1986, 21 children were treated for pineal germinoma, including 16 biopsy-proven, 2 biopsy non-diagnostic, and 3 metastatic unbiopsied (marker negative) patients. Ten of 18 (56%) biopsied patients underwent partial or sub-total tumor resection. Twenty patients were irradiated, 19 of whom are alive. No irradiated patient died of progressive germinoma, but two patients relapsed in the spinal cord and required treatment intensification for salvage. Long-term survivors have significant morbidity. Determination of the minimum effective treatment remains the chief therapeutic challenge.
KW - Pineal germinoma
KW - radiation treatment
UR - http://www.scopus.com/inward/record.url?scp=0025271244&partnerID=8YFLogxK
U2 - 10.1016/0360-3016(90)90058-R
DO - 10.1016/0360-3016(90)90058-R
M3 - Article
C2 - 2318686
AN - SCOPUS:0025271244
SN - 0360-3016
VL - 18
SP - 541
EP - 545
JO - International Journal of Radiation Oncology, Biology, Physics
JF - International Journal of Radiation Oncology, Biology, Physics
IS - 3
ER -