TY - JOUR
T1 - Pituitary neuroendocrine tumors
T2 - a model for neuroendocrine tumor classification
AU - Asa, Sylvia L.
AU - Mete, Ozgur
AU - Cusimano, Michael D.
AU - McCutcheon, Ian E.
AU - Perry, Arie
AU - Yamada, Shozo
AU - Nishioka, Hiroshi
AU - Casar-Borota, Olivera
AU - Uccella, Silvia
AU - La Rosa, Stefano
AU - Grossman, Ashley B.
AU - Ezzat, Shereen
AU - Attendees of the 15th Meeting of the International Pituitary Pathology Club, Istanbul October 2019
AU - Asioli, Sofia
AU - Bozkurt, Suheyla Uyar
AU - Comunoglu, Nil
AU - Cossu, Giulia
AU - Earls, Peter
AU - Gazioglu, Nurperi
AU - Hickman, Richard A.
AU - Ikeda, Hidetoshi
AU - Manojlović‑Gačić, Emilija
AU - Messerer, Mahmoud
AU - Oz, Buge
AU - Pakbaz, Sara
AU - Roncaroli, Federico
AU - Saeger, Wolfgang
AU - Turchini, John
AU - Yarman, Sema
PY - 2021/9
Y1 - 2021/9
N2 - The classification of adenohypophysial neoplasms as “pituitary neuroendocrine tumors” (PitNETs) was proposed in 2017 to reflect their characteristics as epithelial neuroendocrine neoplasms with a spectrum of clinical behaviors ranging from small indolent lesions to large, locally invasive, unresectable tumors. Tumor growth and hormone hypersecretion cause significant morbidity and mortality in a subset of patients. The proposal was endorsed by a WHO working group that sought to provide a unified approach to neuroendocrine neoplasia in all body sites. We review the features that are characteristic of neuroendocrine cells, the epidemiology and prognosis of these tumors, as well as further refinements in terms used for other pituitary tumors to ensure consistency with the WHO framework. The intense study of PitNETs has provided information about the importance of cellular differentiation in tumor prognosis as a model for neuroendocrine tumors in different locations.
AB - The classification of adenohypophysial neoplasms as “pituitary neuroendocrine tumors” (PitNETs) was proposed in 2017 to reflect their characteristics as epithelial neuroendocrine neoplasms with a spectrum of clinical behaviors ranging from small indolent lesions to large, locally invasive, unresectable tumors. Tumor growth and hormone hypersecretion cause significant morbidity and mortality in a subset of patients. The proposal was endorsed by a WHO working group that sought to provide a unified approach to neuroendocrine neoplasia in all body sites. We review the features that are characteristic of neuroendocrine cells, the epidemiology and prognosis of these tumors, as well as further refinements in terms used for other pituitary tumors to ensure consistency with the WHO framework. The intense study of PitNETs has provided information about the importance of cellular differentiation in tumor prognosis as a model for neuroendocrine tumors in different locations.
UR - http://www.scopus.com/inward/record.url?scp=85104867581&partnerID=8YFLogxK
U2 - 10.1038/s41379-021-00820-y
DO - 10.1038/s41379-021-00820-y
M3 - Review article
C2 - 34017065
VL - 34
SP - 1634
EP - 1650
JO - Modern Pathology
JF - Modern Pathology
SN - 0893-3952
IS - 9
ER -