Placebo effects in functional dyspepsia: causes and implications for clinical trials

Michael P. Jones*, Gerald Holtmann

*Corresponding author for this work

Research output: Contribution to journalShort surveypeer-review

6 Citations (Scopus)
12 Downloads (Pure)

Abstract

Placebo responses to an apparently inactive intervention are of interest from a scientific perspective as they suggest possible mechanism(s) at work beyond the intervention itself. They are also of interest from a clinical trials perspective since high rates of placebo response limit the potential to demonstrate worthwhile efficacy of a new intervention. This mini-review was motivated by the work of Bosman and colleagues(Neurogastroenterol Motil, 2022, and e14474) that is published in this issue of the journal in which they report on a systematic review and meta-analysis of placebo response in functional dyspepsia clinical trials. The review sets the scene for their work by putting it in the context of other disorders of brain–gut interaction and extra-gastrointestinal disorders. The review canvasses potential mechanisms of placebo response.

Original languageEnglish
Article numbere14527
Pages (from-to)1-6
Number of pages6
JournalNeurogastroenterology and Motility
Volume35
Issue number2
DOIs
Publication statusPublished - Feb 2023

Bibliographical note

Copyright the Author(s) 2022. Version archived for private and non-commercial use with the permission of the author/s and according to publisher conditions. For further rights please contact the publisher.

Keywords

  • classical conditioning
  • descending pain modulation
  • functional dyspepsia
  • placebo effect
  • placebo response

Fingerprint

Dive into the research topics of 'Placebo effects in functional dyspepsia: causes and implications for clinical trials'. Together they form a unique fingerprint.

Cite this