TY - JOUR
T1 - Placental transfer and foetal disposition of caffeine and its immediate metabolites in the 20-day pregnant rat
T2 - Function of dose
AU - Abdi, F.
AU - Pollard, I.
AU - Wilkinson, J.
PY - 1993
Y1 - 1993
N2 - 1. The dispositions of caffeine and its immediate dimethylxanthine metabolites, theobromine, theophylline and paraxanthine were studied after a single oral dose of 5 and 25 mg/kg caffeine administered to 20-day pregnant and non-pregnant rats, respectively. 2. Peak plasma levels were reached between 1 and 3 h in all fluids and tissues studied. 3. The elimination phase, however, differed significantly between the pregnant and non-pregnant groups. For 25 mg/kg the plasma half-life (t1/2) of caffeine was significantly longer in the pregnant than the non-pregnant group; for 5 mg/kg the elimination rate of caffeine was similar in both groups. 4. AUC values were used to compare caffeine and metabolite exposure in foetal tissues. At 5 mg/kg, peak concentrations for amniotic fluid, foetal blood, liver and kidney were not significantly different from one another. At 25 mg/kg peak levels in foetal liver and kidney were significantly less than those of foetal blood, amniotic fluid or placenta. 5. Because of the observed increase in maternal t1/2 at high dosage, a cautionary note is sounded about caffeine intake in pregnancy.
AB - 1. The dispositions of caffeine and its immediate dimethylxanthine metabolites, theobromine, theophylline and paraxanthine were studied after a single oral dose of 5 and 25 mg/kg caffeine administered to 20-day pregnant and non-pregnant rats, respectively. 2. Peak plasma levels were reached between 1 and 3 h in all fluids and tissues studied. 3. The elimination phase, however, differed significantly between the pregnant and non-pregnant groups. For 25 mg/kg the plasma half-life (t1/2) of caffeine was significantly longer in the pregnant than the non-pregnant group; for 5 mg/kg the elimination rate of caffeine was similar in both groups. 4. AUC values were used to compare caffeine and metabolite exposure in foetal tissues. At 5 mg/kg, peak concentrations for amniotic fluid, foetal blood, liver and kidney were not significantly different from one another. At 25 mg/kg peak levels in foetal liver and kidney were significantly less than those of foetal blood, amniotic fluid or placenta. 5. Because of the observed increase in maternal t1/2 at high dosage, a cautionary note is sounded about caffeine intake in pregnancy.
UR - http://www.scopus.com/inward/record.url?scp=0027156587&partnerID=8YFLogxK
U2 - 10.3109/00498259309057033
DO - 10.3109/00498259309057033
M3 - Article
C2 - 8337902
AN - SCOPUS:0027156587
SN - 0049-8254
VL - 23
SP - 449
EP - 456
JO - Xenobiotica
JF - Xenobiotica
IS - 4
ER -