Planning to conceive within a year is associated with better pregnancy-specific disease-related patient knowledge and better medication adherence in women of childbearing age with inflammatory bowel disease

Christian P. Selinger; Robyn Laube; Helen Steed; Matthew Brookes; NIHR BioResource; Rupert W. L. Leong

doi:10.1177/17562848231193211

Planning to conceive within a year is associated with better pregnancy-specific disease-related patient knowledge and better medication adherence in women of childbearing age with inflammatory bowel disease

Christian P. Selinger^*, Robyn Laube, Helen Steed, Matthew Brookes, NIHR BioResource, Rupert W. L. Leong

^*Corresponding author for this work

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Abstract

Background: Adherence to inflammatory bowel disease (IBD) medication is crucial to maintain remission, especially during pregnancy. Objective: To examine the influence of family planning and pregnancy-related patient knowledge regarding IBD and pregnancy on adherence. Design: Cross-sectional survey study Methods: We surveyed female patients with IBD aged 18–35 years, who at recruitment to the UK IBD BioResource had not had children. We elicited disease and treatment history, demographics and family planning status via an online questionnaire. Patient knowledge as assessed by the validated Crohn’s and Colitis Pregnancy Knowledge Score (CCPKnow) and adherence by visual analogue scale (VAS). Results: In 326 responders (13.8% response rate), good adherence (VAS ⩾ 80) was found in only 38.35%. Disease- and treatment-related factors were not significantly associated with good adherence, except for methotrexate (70.0% adherent of 10 exposed patients versus 37.2% non-exposed; p = 0.036). Patients planning pregnancy for the next year were more often adherent (59.0% versus 35.5%; p = 0.019) and knowledgeable (median CCPKnow 8 versus 7; p = 0.035) compared to those in other family planning categories. Pregnancy-related patient knowledge was significantly associated with adherence (Pearson correlation 0.141; p = 0.015). Adherent patients had significantly higher CCPKnow scores than non-adherent patients (median 8 versus 6; p = 0.009). On binary regression analysis, only planning to conceive within 12 months was independently associated with better adherence (p = 0.016), but not methotrexate exposure (p = 0.076) and CCPKnow (p = 0.056). Conclusions: In a cohort of women of childbearing age with IBD overall medication, adherence was low. Planning to conceive within the next year was associated with better adherence and greater patient knowledge.

Original language	English
Pages (from-to)	1-10
Number of pages	10
Journal	Therapeutic Advances in Gastroenterology
Volume	16
DOIs	https://doi.org/10.1177/17562848231193211
Publication status	Published - 1 Jan 2023

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Copyright the Author(s) 2023. Version archived for private and non-commercial use with the permission of the author/s and according to publisher conditions. For further rights please contact the publisher.

Keywords

inflammatory bowel disease
medication adherence
patient knowledge
pregnancy

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2 Citations
1 Article

Gastroenterology team members’ knowledge and practices with fertility therapy for women with inflammatory bowel disease
Laube, R., Liu, E., Li, Y., Leong, R. W., Limdi, J. & Selinger, C., Mar 2022, In: Therapeutic Advances in Gastroenterology. 15, p. 1-10 10 p.
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Selinger, C. P., Laube, R., Steed, H., Brookes, M., NIHR BioResource, & Leong, R. W. L. (2023). Planning to conceive within a year is associated with better pregnancy-specific disease-related patient knowledge and better medication adherence in women of childbearing age with inflammatory bowel disease. Therapeutic Advances in Gastroenterology, 16, 1-10. https://doi.org/10.1177/17562848231193211

@article{caa09c2b610340e3afbf140bbd2479dd,

title = "Planning to conceive within a year is associated with better pregnancy-specific disease-related patient knowledge and better medication adherence in women of childbearing age with inflammatory bowel disease",

abstract = "Background: Adherence to inflammatory bowel disease (IBD) medication is crucial to maintain remission, especially during pregnancy. Objective: To examine the influence of family planning and pregnancy-related patient knowledge regarding IBD and pregnancy on adherence. Design: Cross-sectional survey study Methods: We surveyed female patients with IBD aged 18–35 years, who at recruitment to the UK IBD BioResource had not had children. We elicited disease and treatment history, demographics and family planning status via an online questionnaire. Patient knowledge as assessed by the validated Crohn{\textquoteright}s and Colitis Pregnancy Knowledge Score (CCPKnow) and adherence by visual analogue scale (VAS). Results: In 326 responders (13.8\% response rate), good adherence (VAS ⩾ 80) was found in only 38.35\%. Disease- and treatment-related factors were not significantly associated with good adherence, except for methotrexate (70.0\% adherent of 10 exposed patients versus 37.2\% non-exposed; p = 0.036). Patients planning pregnancy for the next year were more often adherent (59.0\% versus 35.5\%; p = 0.019) and knowledgeable (median CCPKnow 8 versus 7; p = 0.035) compared to those in other family planning categories. Pregnancy-related patient knowledge was significantly associated with adherence (Pearson correlation 0.141; p = 0.015). Adherent patients had significantly higher CCPKnow scores than non-adherent patients (median 8 versus 6; p = 0.009). On binary regression analysis, only planning to conceive within 12 months was independently associated with better adherence (p = 0.016), but not methotrexate exposure (p = 0.076) and CCPKnow (p = 0.056). Conclusions: In a cohort of women of childbearing age with IBD overall medication, adherence was low. Planning to conceive within the next year was associated with better adherence and greater patient knowledge.",

keywords = "inflammatory bowel disease, medication adherence, patient knowledge, pregnancy",

author = "Selinger, \{Christian P.\} and Robyn Laube and Helen Steed and Matthew Brookes and \{NIHR BioResource\} and Leong, \{Rupert W. L.\}",

note = "Copyright the Author(s) 2023. Version archived for private and non-commercial use with the permission of the author/s and according to publisher conditions. For further rights please contact the publisher.",

year = "2023",

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Selinger, CP, Laube, R, Steed, H, Brookes, M, NIHR BioResource & Leong, RWL 2023, 'Planning to conceive within a year is associated with better pregnancy-specific disease-related patient knowledge and better medication adherence in women of childbearing age with inflammatory bowel disease', Therapeutic Advances in Gastroenterology, vol. 16, pp. 1-10. https://doi.org/10.1177/17562848231193211

Planning to conceive within a year is associated with better pregnancy-specific disease-related patient knowledge and better medication adherence in women of childbearing age with inflammatory bowel disease. / Selinger, Christian P.; Laube, Robyn; Steed, Helen et al.
In: Therapeutic Advances in Gastroenterology, Vol. 16, 01.01.2023, p. 1-10.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Planning to conceive within a year is associated with better pregnancy-specific disease-related patient knowledge and better medication adherence in women of childbearing age with inflammatory bowel disease

AU - Selinger, Christian P.

AU - Laube, Robyn

AU - Steed, Helen

AU - Brookes, Matthew

AU - NIHR BioResource

AU - Leong, Rupert W. L.

N1 - Copyright the Author(s) 2023. Version archived for private and non-commercial use with the permission of the author/s and according to publisher conditions. For further rights please contact the publisher.

PY - 2023/1/1

Y1 - 2023/1/1

N2 - Background: Adherence to inflammatory bowel disease (IBD) medication is crucial to maintain remission, especially during pregnancy. Objective: To examine the influence of family planning and pregnancy-related patient knowledge regarding IBD and pregnancy on adherence. Design: Cross-sectional survey study Methods: We surveyed female patients with IBD aged 18–35 years, who at recruitment to the UK IBD BioResource had not had children. We elicited disease and treatment history, demographics and family planning status via an online questionnaire. Patient knowledge as assessed by the validated Crohn’s and Colitis Pregnancy Knowledge Score (CCPKnow) and adherence by visual analogue scale (VAS). Results: In 326 responders (13.8% response rate), good adherence (VAS ⩾ 80) was found in only 38.35%. Disease- and treatment-related factors were not significantly associated with good adherence, except for methotrexate (70.0% adherent of 10 exposed patients versus 37.2% non-exposed; p = 0.036). Patients planning pregnancy for the next year were more often adherent (59.0% versus 35.5%; p = 0.019) and knowledgeable (median CCPKnow 8 versus 7; p = 0.035) compared to those in other family planning categories. Pregnancy-related patient knowledge was significantly associated with adherence (Pearson correlation 0.141; p = 0.015). Adherent patients had significantly higher CCPKnow scores than non-adherent patients (median 8 versus 6; p = 0.009). On binary regression analysis, only planning to conceive within 12 months was independently associated with better adherence (p = 0.016), but not methotrexate exposure (p = 0.076) and CCPKnow (p = 0.056). Conclusions: In a cohort of women of childbearing age with IBD overall medication, adherence was low. Planning to conceive within the next year was associated with better adherence and greater patient knowledge.

AB - Background: Adherence to inflammatory bowel disease (IBD) medication is crucial to maintain remission, especially during pregnancy. Objective: To examine the influence of family planning and pregnancy-related patient knowledge regarding IBD and pregnancy on adherence. Design: Cross-sectional survey study Methods: We surveyed female patients with IBD aged 18–35 years, who at recruitment to the UK IBD BioResource had not had children. We elicited disease and treatment history, demographics and family planning status via an online questionnaire. Patient knowledge as assessed by the validated Crohn’s and Colitis Pregnancy Knowledge Score (CCPKnow) and adherence by visual analogue scale (VAS). Results: In 326 responders (13.8% response rate), good adherence (VAS ⩾ 80) was found in only 38.35%. Disease- and treatment-related factors were not significantly associated with good adherence, except for methotrexate (70.0% adherent of 10 exposed patients versus 37.2% non-exposed; p = 0.036). Patients planning pregnancy for the next year were more often adherent (59.0% versus 35.5%; p = 0.019) and knowledgeable (median CCPKnow 8 versus 7; p = 0.035) compared to those in other family planning categories. Pregnancy-related patient knowledge was significantly associated with adherence (Pearson correlation 0.141; p = 0.015). Adherent patients had significantly higher CCPKnow scores than non-adherent patients (median 8 versus 6; p = 0.009). On binary regression analysis, only planning to conceive within 12 months was independently associated with better adherence (p = 0.016), but not methotrexate exposure (p = 0.076) and CCPKnow (p = 0.056). Conclusions: In a cohort of women of childbearing age with IBD overall medication, adherence was low. Planning to conceive within the next year was associated with better adherence and greater patient knowledge.

KW - inflammatory bowel disease

KW - medication adherence

KW - patient knowledge

KW - pregnancy

UR - https://www.scopus.com/pages/publications/85169790443

U2 - 10.1177/17562848231193211

DO - 10.1177/17562848231193211

M3 - Article

C2 - 37667806

AN - SCOPUS:85169790443

SN - 1756-283X

VL - 16

SP - 1

EP - 10

JO - Therapeutic Advances in Gastroenterology

JF - Therapeutic Advances in Gastroenterology

ER -

Selinger CP, Laube R, Steed H, Brookes M, NIHR BioResource, Leong RWL. Planning to conceive within a year is associated with better pregnancy-specific disease-related patient knowledge and better medication adherence in women of childbearing age with inflammatory bowel disease. Therapeutic Advances in Gastroenterology. 2023 Jan 1;16:1-10. doi: 10.1177/17562848231193211

Planning to conceive within a year is associated with better pregnancy-specific disease-related patient knowledge and better medication adherence in women of childbearing age with inflammatory bowel disease

Abstract

Bibliographical note

Keywords

Access to Document

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Fingerprint

Research output

Gastroenterology team members’ knowledge and practices with fertility therapy for women with inflammatory bowel disease

Cite this