Plasma apolipoproteins and physical and cognitive health in very old individuals

Julia Muenchhoff, Fei Song, Anne Poljak, John D. Crawford, Karen A. Mather, Nicole A. Kochan, Zixuan Yang, Julian N. Trollor, Simone Reppermund, Kate Maston, Adam Theobald, Susanne Kirchner-Adelhardt, John B. Kwok, Robyn L. Richmond, Mark McEvoy, John Attia, Peter W. Schofield, Henry Brodaty, Perminder S. Sachdev*

*Corresponding author for this work

Research output: Contribution to journalArticle

19 Citations (Scopus)


Apolipoproteins play a crucial role in lipid metabolism with implications in cardiovascular disease, obesity, diabetes, Alzheimer's disease, and longevity. We quantified 7 apolipoproteins in plasma in 1067 individuals aged 56–105 using immunoassays and explored relationships with APOE polymorphism ε2/3/4, vascular health, frailty, and cognition. ApoA1, ApoA2, ApoB, ApoC3, ApoE, ApoH, and ApoJ decreased from mid-life, although ApoE and ApoJ had U-shaped trends. Centenarians had the highest ApoE levels and the lowest frequency of APOE ε4 allele relative to younger groups. Apolipoprotein levels trended lower in APOE ε4 homozygotes and heterozygotes compared with noncarriers, with ApoE and ApoJ being significantly lower. Levels of all apolipoproteins except ApoH were higher in females. Sex- and age-related differences were apparent in the association of apolipoproteins with cognitive performance, as only women had significant negative associations of ApoB, ApoE, ApoH, and ApoJ in mid-life, whereas associations at older age were nonsignificant or positive. Our findings suggest levels of some apolipoproteins, especially ApoE, are associated with lifespan and cognitive function in exceptionally long-lived individuals.

Original languageEnglish
Pages (from-to)49-60
Number of pages12
JournalNeurobiology of Aging
Publication statusPublished - 1 Jul 2017
Externally publishedYes


  • longevity
  • cognition
  • lipids
  • APOE phenotype
  • centenarian
  • frailty

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