Plasma F2-isoprostane levels are increased in Alzheimer's disease: evidence of increased oxidative stress in vivo

Emma Waddington*, Kevin Croft, Roger Clarnette, Trevor Mori, Ralph Martins

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

37 Citations (Scopus)

Abstract

Alzheimer's Disease (AD) is a neurodegenerative disorder that is immunochemically characterised by brain lesions rich in the 4kDa peptide amyloid-β (Aβ). It has been postulated that oxidative stress may play a role in the pathogenesis of AD. F2-isoprostanes, which are chemically stable peroxidation products of arachidonic acid, were measured in plasma and urine from 20 AD and 20 age-matched controls by GC-MS. Individuals with AD were observed to have significantly higher levels of plasma F2-isoprostanes when compared to their age-matched controls (p<0.01). Female subjects were shown to have a significantly higher level of plasma F2-isoprostanes when compared to male subjects (p<0.05). This study provides evidence in support of the hypothesis that oxidative stress, and hence lipid peroxidation may play a role in the neurodegeneration associated with AD.

Original languageEnglish
Pages (from-to)277-282
Number of pages6
JournalAlzheimer's Reports
Volume2
Issue number5
Publication statusPublished - 1999
Externally publishedYes

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