Plasma glucocorticoid elevation and desynchronization of the estrous cycle following unpredictable stress in the rat

Irina Pollard*, Barbara M. White, J. R. Bassett, K. D. Cairncross

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

53 Citations (Scopus)

Abstract

Exposure of female Wistar rats to a signalled unpredictable 5-day stress regimen induced extreme plasma corticosterone elevation at all four stages of the estrous cycle. The corticosterone level at proestrus was significantly higher than at the other three stages of the cycle in both control and stressed groups. This rise in plasma corticosterone became evident only in late proestrus. It was observed that the estrous cycles of 50% of the rats became desynchronized over the 5-day stress period; a steroid hormone imbalance is suggested as a possible factor contributing to this desynchrony.

Original languageEnglish
Pages (from-to)103-108
Number of pages6
JournalBehavioral Biology
Volume14
Issue number1
DOIs
Publication statusPublished - 1975

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