Pleural fluid and serum eosinophilia: Association with fluoxetine hydrochloride

Mehrdad Behnia*, Ian Dowdeswell, Saeed Vakili

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

17 Citations (Scopus)


We report the case of a patient who was treated with fluoxetine hydrochloride (Prozac) for depression. Approximately 8 weeks into the treatment, an eosinophillc pleural effusion and serum eosinophilia developed. An extensive workup for the etiology of eosinophilic pleural effusion was unrevealing. Pleural biopsy showed a nonspecific inflammatory reaction and mild fibrosis. The pleural effusion and eosinophilia resolved within a few weeks of cessation of the drug. Fluoxetine can be associated with pleural and serum eosinophilia, possibly through an allergic-mediated reaction.

Original languageEnglish
Pages (from-to)611-613
Number of pages3
JournalSouthern Medical Journal
Issue number6
Publication statusPublished - 2000
Externally publishedYes


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