ЭКСПЕРИМЕНТАЛЬНОЕ ОБОСНОВАНИЕ СОЗДАНИЯ ГИБРИДНОЙ МАТРИЦЫ И ТКАНЕИНЖЕНЕРНОЙ КОНСТРУКЦИИ НА ОСНОВЕ СЕТКИ ИЗ ПОЛИЛАКТОГЛИКОЛИДА И РЕКОНСТРУИРОВАННОГО КОЛЛАГЕНА С ЦЕЛЬЮ ПОСЛЕДУЮЩЕЙ ЗАМЕСТИТЕЛЬНОЙ УРЕТРОПЛАСТИКИ

Translated title of the contribution: PLGA mesh-collagen hybrid scaffold and tissue-engineered product in substitution urethroplasty: experimental validation

P. V. Glybochko, Y. G. Alyaev, A. B. Shekhter, A. Z. Vinarov, L. P. Istranov, E. V. Istranova, R. K. Aboyants, A. V. Lyundup, M. E. Krasheninnikov, A. E. Guller, D. V. Butnaru, L. V. Marisov, D. F. Kantimerov, A. V. Kurkov, E. I. Safronova, E. A. Vorobeva, M. M. Iritsyan

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)

Abstract

Urethral strictures are a pressing issue in modern medicine. Substitution urethroplasty is considered one of the most effective treatment methods. However, despite the surgery showing good results, many problems remain unresolved, one being substitute material deficiency in extensive or recurrent strictures, as well as in cases requiring multistage surgeries, including those used to treat hypospadias. Graft removal also leaves the donor area prone to diseases and increases the length of surgery leading to a higher risk of intra- and postoperative complications. Tissue engineering (namely tissue-engineered products comprised of scaffolds and cells) may be a useful tool in dealing with these issues. The authors assessed the characteristics of a novel hybrid scaffold created from "reconstructed" collagen and a poly(lactic-co-glycolic acid) mesh. The resulting composite product showed good mechanical properties and functional performance. The hybrid scaffold was non-cytotoxic and provided an adequate base for cell adhesion and proliferation. Biodegradation resulted in the scaffold being replaced by urothelium and urethral mucosa. The newly formed tissues possessed adequate structural and functional properties. Only one rabbit out of 12 developed urethral stricture at the site of scaffold implantation. The above-mentioned facts suggest that the novel hybrid scaffold is a promising tissue-engineered product with potential implication in substitution urethroplasty.

Translated title of the contributionPLGA mesh-collagen hybrid scaffold and tissue-engineered product in substitution urethroplasty: experimental validation
Original languageRussian
Pages (from-to)5-13
Number of pages9
JournalUrologiia (Moscow, Russia : 1999)
Issue number6
Publication statusPublished - 1 Dec 2015
Externally publishedYes

Keywords

  • regenerative medicine
  • scaffolds
  • substitution urethropasty
  • tissue engineering
  • tissue-engineered products
  • urethral strictures

Fingerprint Dive into the research topics of 'PLGA mesh-collagen hybrid scaffold and tissue-engineered product in substitution urethroplasty: experimental validation'. Together they form a unique fingerprint.

Cite this