Point-of-use rapid detection of SARS-CoV-2: Nanotechnology-enabled solutions for the COVID-19 pandemic

Navid Rabiee, Mojtaba Bagherzadeh, Amir Ghasemi, Hossein Zare, Sepideh Ahmadi, Yousef Fatahi, Rassoul Dinarvand, Mohammad Rabiee, Seeram Ramakrishna, Mohammadreza Shokouhimehr*, Rajender S. Varma

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

103 Citations (Scopus)
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Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) caused the COVID-19 pandemic that has been spreading around the world since December 2019. More than 10 million affected cases and more than half a million deaths have been reported so far, while no vaccine is yet available as a treatment. Considering the global healthcare urgency, several techniques, including whole genome sequencing and computed tomography imaging have been employed for diagnosing infected people. Considerable efforts are also directed at detecting and preventing different modes of community transmission. Among them is the rapid detection of virus presence on different surfaces with which people may come in contact. Detection based on non-contact optical techniques is very helpful in managing the spread of the virus, and to aid in the disinfection of surfaces. Nanomaterial-based methods are proven suitable for rapid detection. Given the immense need for science led innovative solutions, this manuscript critically reviews recent literature to specifically illustrate nano-engineered effective and rapid solutions. In addition, all the different techniques are critically analyzed, compared, and contrasted to identify the most promising methods. Moreover, promising research ideas for high accuracy of detection in trace concentrations, via color change and light-sensitive nanostructures, to assist fingerprint techniques (to identify the virus at the contact surface of the gas and solid phase) are also presented.

Original languageEnglish
Article number5126
Pages (from-to)1-24
Number of pages24
JournalInternational Journal of Molecular Sciences
Issue number14
Publication statusPublished - 20 Jul 2020
Externally publishedYes

Bibliographical note

© 2020 by the authors. Licensee MDPI, Basel, Switzerland. Version archived for private and non-commercial use with the permission of the author/s and according to publisher conditions. For further rights please contact the publisher.


  • COVID-19
  • Nanoparticles
  • Nanotechnology
  • Point-of-use
  • Rapid detection of virus
  • SARS-CoV-2


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