Point spread function optimization in SPECT

A. Bousse*, N. Fuin, K. Erlandsson, S. Pedemonte, D. Kazantsev, S. Ourselin, S. Arridge, B. F. Hutton

*Corresponding author for this work

    Research output: Chapter in Book/Report/Conference proceedingConference proceeding contributionpeer-review

    1 Citation (Scopus)

    Abstract

    In this paper we propose a novel method for collimator design in single photon emission tomography (SPECT). The challenge here is to find a practical collimator design that allows good recovery and good sensitivity. Instead of working on the collimator's shape, the problem is addressed by optimizing the point spread function (PSF) with respect to the performance of the reconstruction algorithm in terms of resolution modelling. The optimization is based on an object-dependent cost function that takes into account bother recovery coefficient (RC) and sensitivity. Therefore, for each object considered a different optimal PSF is expected. Once a PSF is obtained, we assess its performances by plotting the coefficient of variation (COV) versus the recovery coefficient (RC) at each iteration of a maximum likelihood maximization expectation (MLEM) algorithm. We performed our experiments on two-dimensional (2-D) geometric phantoms, in order to investigate the relationship between the optimal PSF and the object geometrical properties, as well as on a 2-D brain activity phantom. We show that the optimized PSF's lead to resolution models that improve both image resolution and signal to noise ratio.

    Original languageEnglish
    Title of host publicationIEEE Nuclear Science Symposuim and Medical Imaging Conference, NSS/MIC 2010
    Pages2061-2065
    Number of pages5
    DOIs
    Publication statusPublished - 2010
    Event2010 IEEE Nuclear Science Symposium, Medical Imaging Conference, NSS/MIC 2010 and 17th International Workshop on Room-Temperature Semiconductor X-ray and Gamma-ray Detectors, RTSD 2010 - Knoxville, TN, United States
    Duration: 30 Oct 20106 Nov 2010

    Other

    Other2010 IEEE Nuclear Science Symposium, Medical Imaging Conference, NSS/MIC 2010 and 17th International Workshop on Room-Temperature Semiconductor X-ray and Gamma-ray Detectors, RTSD 2010
    CountryUnited States
    CityKnoxville, TN
    Period30/10/106/11/10

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