Polyaniline functionalized graphene nanoelectrodes for the regeneration of PC12 cells via electrical stimulation

Zheng Zheng, Libin Huang, Lu Yan, Feng Yuan, Lefeng Wang, Ke Wang, Tom Lawson, Mimi Lin*, Yong Liu

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

10 Citations (Scopus)
6 Downloads (Pure)

Abstract

The regeneration of neurons is an important goal of neuroscience and clinical medicine. The electrical stimulation of cells is a promising technique to meet this goal. However, its efficiency highly depends on the electrochemical properties of the stimulation electrodes used. This work reports on the preparation and use of a highly electroactive and biocompatible nanoelectrode made from a novel polyaniline functionalized graphene composite. This nanocomposite was prepared using a facile and efficient polymerization-enhanced ball-milling method. It was used to stimulate the growth of PC12 cells under various electrical fields. The enhanced growth of axons and improved wound regeneration of PC12 cells were observed after this treatment, suggesting a promising strategy for neuro traumatology.

Original languageEnglish
Article number2013
Pages (from-to)1-11
Number of pages11
JournalInternational Journal of Molecular Sciences
Volume20
Issue number8
DOIs
Publication statusPublished - 24 Apr 2019

Bibliographical note

Version archived for private and non-commercial use with the permission of the author/s and according to publisher conditions. For further rights please contact the publisher.

Keywords

  • Electrical stimulation
  • Graphene
  • Neuroregeneration
  • PC12 cells
  • Polyaniline

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