Polymeric nanoparticles for mitochondria targeting mediated robust cancer therapy

Yajing Sun, Qingshan Yang , Xue Xia, Xiaozhe Li, Weimin Ruan, Meng Zheng, Yan Zou, Bingyang Shi

Research output: Contribution to journalReview articlepeer-review

6 Citations (Scopus)
125 Downloads (Pure)


Despite all sorts of innovations in medical researches over the past decades, cancer remains a major threat to human health. Mitochondria are essential organelles in eukaryotic cells, and their dysfunctions contribute to numerous diseases including cancers. Mitochondria-targeted cancer therapy, which specifically delivers drugs into the mitochondria, is a promising strategy for enhancing anticancer treatment efficiency. However, owing to their special double-layered membrane system and highly negative potentials, mitochondria remain a challenging target for therapeutic agents to reach and access. Polymeric nanoparticles exceed in cancer therapy ascribed to their unique features including ideal biocompatibility, readily design and synthesis, as well as flexible ligand decoration. Significant efforts have been put forward to develop mitochondria-targeted polymeric nanoparticles. In this review, we focused on the smart design of polymeric nanosystems for mitochondria targeting and summarized the current applications in improving cancer therapy.
Original languageEnglish
Article number755727
Pages (from-to)1-11
Number of pages11
JournalFrontiers in Bioengineering and Biotechnology
Publication statusPublished - 2021

Bibliographical note

Copyright the Author(s) 2021. Version archived for private and non-commercial use with the permission of the author/s and according to publisher conditions. For further rights please contact the publisher.


  • drug delivery
  • cancer therapy
  • mitochondria
  • polymers
  • nanoparticles


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