Pomegranate is a natural plant product which has demonstrated a multitude of beneficial health benefits. Current in vitro and in vivo research have shown that this age-old fruit is composed of natural polyphenolic phytochemicals which exhibit diverse pharmacological potency and potent antioxidant, anti-inflammatory, and antimicrobial/antiviral properties. Pomegranates are also being considered as a cancer chemo-preventive and neuroprotective agents. This book discusses the implications of pomegranate consumption for the management and treatment of an array of cardiovascular diseases, cancers, and neurodegenerative disorders. New cultivation techniques to improve pomegranate production are also discussed.