Purpose: To report a case series of popper maculopathy. Methods: Clinical history, examination findings, retinal imaging, and progress of the disease are described. Results: Four male patients with a mean age of 37 years (range 25-48) and different duration of popper use (ranging from first time user to chronic user) presented with central scotomata, phosphenes, or photophobia. Optical coherence tomography in all cases demonstrated subfoveal disruption of the ellipsoid zone. Three cases also showed hyperreflectivity of the ellipsoid zone, and one case had a foveal detachment. Chronic user of poppers was associated with more severe macular changes. One patient had a 3-year follow-up and demonstrated complete resolution of signs on retinal imaging after ceasing popper use. Conclusion: Popper maculopathy may show complete resolution of signs on long-term follow-up, even after chronic popper ingestion.