Pore structure and particle shape modulates the protein corona of mesoporous silica particles

Kalpeshkumar Giri; Inga Kuschnerus; Michael Lau; Juanfang Ruan; Alfonso Garcia-Bennett

doi:10.1039/d0ma00188k

Pore structure and particle shape modulates the protein corona of mesoporous silica particles

Kalpeshkumar Giri, Inga Kuschnerus, Michael Lau, Juanfang Ruan, Alfonso Garcia-Bennett^*

^*Corresponding author for this work

ARC Centre of Excellence for Nanoscale BioPhotonics (CNBP)

Research output: Contribution to journal › Article › peer-review

5 Citations (Scopus)

39 Downloads (Pure)

Abstract

The protein corona of mesoporous silica particles is significantly affected by their morphology, pore structure and size. High aspect ratio particles with large 12 nm pores have a high proportion of low molecular weight proteins in comparison to spherical particles with 5 nm pores, which show a homogenous protein coating which is generally constant in protein composition after long incubation times in serum. The pre-formation of a protein corona prior to incubation with microglia cells enhances the cellular uptake of spherical particles but not facetted or high aspect ratio particles.

Original language	English
Pages (from-to)	599-603
Number of pages	5
Journal	Materials Advances
Volume	1
Issue number	4
DOIs	https://doi.org/10.1039/d0ma00188k
Publication status	Published - 1 Jul 2020

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Version archived for private and non-commercial use with the permission of the author/s and according to publisher conditions. For further rights please contact the publisher.

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10.1039/d0ma00188k

Publisher version (open access)Final published version, 2.28 MBLicence: CC BY-NC

Cite this

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abstract = "The protein corona of mesoporous silica particles is significantly affected by their morphology, pore structure and size. High aspect ratio particles with large 12 nm pores have a high proportion of low molecular weight proteins in comparison to spherical particles with 5 nm pores, which show a homogenous protein coating which is generally constant in protein composition after long incubation times in serum. The pre-formation of a protein corona prior to incubation with microglia cells enhances the cellular uptake of spherical particles but not facetted or high aspect ratio particles.",

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AU - Kuschnerus, Inga

AU - Lau, Michael

AU - Ruan, Juanfang

AU - Garcia-Bennett, Alfonso

N1 - Version archived for private and non-commercial use with the permission of the author/s and according to publisher conditions. For further rights please contact the publisher.

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N2 - The protein corona of mesoporous silica particles is significantly affected by their morphology, pore structure and size. High aspect ratio particles with large 12 nm pores have a high proportion of low molecular weight proteins in comparison to spherical particles with 5 nm pores, which show a homogenous protein coating which is generally constant in protein composition after long incubation times in serum. The pre-formation of a protein corona prior to incubation with microglia cells enhances the cellular uptake of spherical particles but not facetted or high aspect ratio particles.

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Pore structure and particle shape modulates the protein corona of mesoporous silica particles

Abstract

Bibliographical note

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In Situ studies of the formation of the Protein Corona

The Protein Corona: Imaging the nanoparticle biological identity card

Cite this

Pore structure and particle shape modulates the protein corona of mesoporous silica particles

Abstract

Bibliographical note

Access to Document

Other files and links

Fingerprint

Projects

In Situ studies of the formation of the Protein Corona

The Protein Corona: Imaging the nanoparticle biological identity card

Cite this