Pore structure and particle shape modulates the protein corona of mesoporous silica particles

Kalpeshkumar Giri, Inga Kuschnerus, Michael Lau, Juanfang Ruan, Alfonso Garcia-Bennett*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

5 Downloads (Pure)

Abstract

The protein corona of mesoporous silica particles is significantly affected by their morphology, pore structure and size. High aspect ratio particles with large 12 nm pores have a high proportion of low molecular weight proteins in comparison to spherical particles with 5 nm pores, which show a homogenous protein coating which is generally constant in protein composition after long incubation times in serum. The pre-formation of a protein corona prior to incubation with microglia cells enhances the cellular uptake of spherical particles but not facetted or high aspect ratio particles.

Original languageEnglish
Pages (from-to)599-603
Number of pages5
JournalMaterials Advances
Volume1
Issue number4
DOIs
Publication statusPublished - 1 Jul 2020

Bibliographical note

Version archived for private and non-commercial use with the permission of the author/s and according to publisher conditions. For further rights please contact the publisher.

Cite this