Projects per year
Abstract
The protein corona of mesoporous silica particles is significantly affected by their morphology, pore structure and size. High aspect ratio particles with large 12 nm pores have a high proportion of low molecular weight proteins in comparison to spherical particles with 5 nm pores, which show a homogenous protein coating which is generally constant in protein composition after long incubation times in serum. The pre-formation of a protein corona prior to incubation with microglia cells enhances the cellular uptake of spherical particles but not facetted or high aspect ratio particles.
Original language | English |
---|---|
Pages (from-to) | 599-603 |
Number of pages | 5 |
Journal | Materials Advances |
Volume | 1 |
Issue number | 4 |
DOIs | |
Publication status | Published - 1 Jul 2020 |
Bibliographical note
Version archived for private and non-commercial use with the permission of the author/s and according to publisher conditions. For further rights please contact the publisher.Fingerprint
Dive into the research topics of 'Pore structure and particle shape modulates the protein corona of mesoporous silica particles'. Together they form a unique fingerprint.Projects
- 2 Finished
-
In Situ studies of the formation of the Protein Corona
Garcia-Bennett, A., Kuschnerus, I. & Bedford, N.
10/11/18 → 12/11/18
Project: Research
File -
The Protein Corona: Imaging the nanoparticle biological identity card
Garcia-Bennett, A., MQRES (International), M. & MQRES, M.
1/04/16 → 3/04/20
Project: Research