Pore structure and particle shape modulates the protein corona of mesoporous silica particles

Kalpeshkumar Giri, Inga Kuschnerus, Michael Lau, Juanfang Ruan, Alfonso Garcia-Bennett*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)
7 Downloads (Pure)

Abstract

The protein corona of mesoporous silica particles is significantly affected by their morphology, pore structure and size. High aspect ratio particles with large 12 nm pores have a high proportion of low molecular weight proteins in comparison to spherical particles with 5 nm pores, which show a homogenous protein coating which is generally constant in protein composition after long incubation times in serum. The pre-formation of a protein corona prior to incubation with microglia cells enhances the cellular uptake of spherical particles but not facetted or high aspect ratio particles.

Original languageEnglish
Pages (from-to)599-603
Number of pages5
JournalMaterials Advances
Volume1
Issue number4
DOIs
Publication statusPublished - 1 Jul 2020

Bibliographical note

Version archived for private and non-commercial use with the permission of the author/s and according to publisher conditions. For further rights please contact the publisher.

Fingerprint

Dive into the research topics of 'Pore structure and particle shape modulates the protein corona of mesoporous silica particles'. Together they form a unique fingerprint.

Cite this