TY - JOUR
T1 - Possible altered mineral metabolism in human anencephalic fetuses
AU - Friel, James K.
AU - Longerich, Henry
AU - Jackson, Simon E.
AU - Pushpananthan, Chitra
AU - Wright, James R.
PY - 2005/2
Y1 - 2005/2
N2 - Neural tube defects are congenital abnormalities caused by failure of the neural tube to close during embryogenesis. We investigated trace elements (zinc, copper, manganese, cobalt, nickel, molybdenum, cadmium), livers, pancreata, sciatic nerves, diaphragms, and kidneys collected at autopsy from 33 anencephalic fetuses and 22 control fetuses. Collections were done on the right side using a titanium scalpel, plastic forceps, and acid-washed materials. Samples were wet ashed and analyzed using inductively coupled plasma mass spectrometry. The gestational age and birth weight (mean ± SD) of anencephalic fetuses were 25.8 ± 8 weeks and 729 ± 879 g, respectively; those of control fetuses, 28 ± 8 weeks and 1340 ± 1216 g, respectively. Liver concentrations (ppm, dry weight, mean ± SEM) of Zn (1075 ± 56 vs 668 ± 75; P =. 001) increased in anencephalic fetuses, suggesting defective transport of Zn. Whether this is part of the cause of neural tube defects or a result of the disease is unclear.
AB - Neural tube defects are congenital abnormalities caused by failure of the neural tube to close during embryogenesis. We investigated trace elements (zinc, copper, manganese, cobalt, nickel, molybdenum, cadmium), livers, pancreata, sciatic nerves, diaphragms, and kidneys collected at autopsy from 33 anencephalic fetuses and 22 control fetuses. Collections were done on the right side using a titanium scalpel, plastic forceps, and acid-washed materials. Samples were wet ashed and analyzed using inductively coupled plasma mass spectrometry. The gestational age and birth weight (mean ± SD) of anencephalic fetuses were 25.8 ± 8 weeks and 729 ± 879 g, respectively; those of control fetuses, 28 ± 8 weeks and 1340 ± 1216 g, respectively. Liver concentrations (ppm, dry weight, mean ± SEM) of Zn (1075 ± 56 vs 668 ± 75; P =. 001) increased in anencephalic fetuses, suggesting defective transport of Zn. Whether this is part of the cause of neural tube defects or a result of the disease is unclear.
KW - Cadmium
KW - Human fetus
KW - Neural tube defects
KW - Zinc
UR - http://www.scopus.com/inward/record.url?scp=14644442328&partnerID=8YFLogxK
U2 - 10.1016/j.nutres.2004.10.007
DO - 10.1016/j.nutres.2004.10.007
M3 - Article
AN - SCOPUS:14644442328
SN - 0271-5317
VL - 25
SP - 103
EP - 109
JO - Nutrition Research
JF - Nutrition Research
IS - 2
ER -