Possible role of common spices as a preventive and therapeutic agent for Alzheimer's disease

Omid Mirmosayyeb, Amirpouya Tanhaei, Hamid R. Sohrabi, Ralph N. Martins, Mana Tanhaei, Mohammad Amin Najafi, Ali Safaei, Rokhsareh Meamar

Research output: Contribution to journalArticle

12 Citations (Scopus)
7 Downloads (Pure)

Abstract

For centuries, spices have been consumed as food additives or medicinal agents. However, there is increasing evidence indicating the plant-based foods in regular diet may lower the risk of neurodegenerative diseases including Alzheimer disease. Spices, as one of the most commonly used plant-based food additives may provide more than just flavors, but as agents that may prevent or even halt neurodegenerative processes associated with aging. In this article, we review the role and application of five commonly used dietary spices including saffron turmeric, pepper family, zingiber, and cinnamon. Besides suppressing inflammatory pathways, these spices may act as antioxidant and inhibit acetyl cholinesterase and amyloid β aggregation. We summarized how spice-derived nutraceuticals mediate such different effects and what their molecular targets might be. Finally, some directions for future research are briefly discussed.

Original languageEnglish
Article number5
Pages (from-to)1-8
Number of pages8
JournalInternational Journal of Preventive Medicine
Volume8
DOIs
Publication statusPublished - 2017
Externally publishedYes

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Bibliographical note

Copyright the International Journal of Preventive Medicine 2017. Version archived for private and non-commercial use with the permission of the author/s and according to publisher conditions. For further rights please contact the publisher.

Keywords

  • Alzheimer' disease
  • dementia
  • spice
  • Alzheimer’s disease
  • Spice
  • Dementia

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