Post-coma disturbance and post-traumatic amnesia as nonlinear predictors of cognitive outcome following severe closed head injury: Findings from the Westmead head injury project

C. Haslam, J. Batchelor, M. R. Fearnside, S. A. Haslam, S. Hawkins, E. Kenway

Research output: Contribution to journalArticleResearchpeer-review

Abstract

This study sought to identify combinations of early neurological variables which best predict cognitive outcome 12 months after severe head injury. At the time of admission patients were assessed on seven neurological indices. Twelve months later a battery of neuropsychological tests examining recent memory functioning and speed of information processing was administered. Recent memory functioning was best predicted by a combination of post-coma disturbance (PCD; i.e. the duration of post-traumatic amnesia, PTA, minus the duration of coma) and presence of subarachnoid haemorrhage (multiple r == 0.54, p<0.001). Speed of information processing was best predicted by the duration of PTA (r==0.35,P<0.01). However, thesc conclusions were based on square root transformation of PCD and PTA variables. The success of this transformation in assisting prediction confirms suggestions that the relationship between PTA and cognitive outcome is nonlinear.

LanguageEnglish
Pages519-528
Number of pages10
JournalBrain Injury
Volume8
Issue number6
DOIs
Publication statusPublished - 1994
Externally publishedYes

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Post-Head Injury Coma
Closed Head Injuries
Amnesia
Coma
Automatic Data Processing
Craniocerebral Trauma
Neuropsychological Tests
Patient Admission
Subarachnoid Hemorrhage
Head Injury
Predictors
Closed Head Injury
Information Processing

Cite this

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title = "Post-coma disturbance and post-traumatic amnesia as nonlinear predictors of cognitive outcome following severe closed head injury: Findings from the Westmead head injury project",
abstract = "This study sought to identify combinations of early neurological variables which best predict cognitive outcome 12 months after severe head injury. At the time of admission patients were assessed on seven neurological indices. Twelve months later a battery of neuropsychological tests examining recent memory functioning and speed of information processing was administered. Recent memory functioning was best predicted by a combination of post-coma disturbance (PCD; i.e. the duration of post-traumatic amnesia, PTA, minus the duration of coma) and presence of subarachnoid haemorrhage (multiple r == 0.54, p<0.001). Speed of information processing was best predicted by the duration of PTA (r==0.35,P<0.01). However, thesc conclusions were based on square root transformation of PCD and PTA variables. The success of this transformation in assisting prediction confirms suggestions that the relationship between PTA and cognitive outcome is nonlinear.",
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Post-coma disturbance and post-traumatic amnesia as nonlinear predictors of cognitive outcome following severe closed head injury : Findings from the Westmead head injury project. / Haslam, C.; Batchelor, J.; Fearnside, M. R.; Haslam, S. A.; Hawkins, S.; Kenway, E.

In: Brain Injury, Vol. 8, No. 6, 1994, p. 519-528.

Research output: Contribution to journalArticleResearchpeer-review

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