Abstract
Acute kidney injury (AKI) occurs commonly in patients requiring mechanical circulatory support (MCS) after cardiothoracic surgery. The prognostic implications of AKI in this patient group relate closely to the pathophysiology and risk factors associated with the underlying disease; pre-operative, intra-operative, and post-operative variables; hemodynamic factors; and type of support device used. General approaches to AKI management, including prevention strategies, medical management, and hemodynamic support, are also applicable in patients requiring MCS. Approaches to renal replacement therapy vary depend on patient factors, device-specific factors, and local preferences and experience. In this invited narrative review, we discuss the pathophysiology, risk factors, and prognostic implications of AKI in post-operative adult patients following institution of MCS. Management strategies for AKI are presented with a focus on those supported with either extracorporeal membrane oxygenation or a ventricular assist device.
Original language | English |
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Article number | 833 |
Pages (from-to) | 1-15 |
Number of pages | 16 |
Journal | Annals of Translational Medicine |
Volume | 8 |
Issue number | 13 |
DOIs | |
Publication status | Published - Jul 2020 |
Bibliographical note
Copyright the Publisher. Version archived for private and non-commercial use with the permission of the author/s and according to publisher conditions. For further rights please contact the publisher.Keywords
- Mechanical circulatory support (MCS)
- acute kidney injury (AKI)
- extracorporeal membrane oxygenation (ECMO)
- left ventricular assist device (LVAD)