Post-partum catastrophic antiphospholipid syndrome presenting with shock and digital ischaemia

a diagnostic and management challenge

Victoria Sadick*, Stuart Lane, Eddy Fischer, Ian Seppelt, Anita Shetty, Anthony McLean

*Corresponding author for this work

Research output: Contribution to journalArticle

1 Citation (Scopus)


Catastrophic antiphospholipid syndrome is a rare multisystem autoimmune condition characterised by rapid development of widespread thrombotic disease and subsequent multi-organ failure. It is the most severe complication of antiphospholipid syndrome, carrying significant morbidity and mortality. We report a patient with post-partum catastrophic antiphospholipid syndrome with cardiac, hepatic, renal and cutaneous manifestations. The diagnostic challenges in establishing a definitive diagnosis in catastrophic antiphospholipid syndrome is discussed, along with the difficulties in managing these patients in the intensive care unit.

Original languageEnglish
Pages (from-to)357-364
Number of pages8
JournalJournal of the Intensive Care Society
Issue number4
Publication statusPublished - 1 Nov 2018
Externally publishedYes


  • Catastrophic antiphospholipid syndrome
  • multi-organ failure
  • pregnancy
  • shock
  • thrombosis

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