TY - JOUR
T1 - Posterior fossa medulloblastoma in childhood
T2 - Treatment results and a proposal for a new staging system
AU - Jenkin, Derek
AU - Goddard, Karen
AU - Armstrong, Derek
AU - Becker, Laurence
AU - Berry, Martin
AU - Chan, Helen
AU - Doherty, Mary
AU - Greenberg, Mark
AU - Hendrick, Bruce
AU - Hoffman, Harold
AU - Humphreys, Robin
AU - Sonley, Marilyn
AU - Weitzman, Sheila
AU - Zipursky, Al
PY - 1990
Y1 - 1990
N2 - Seventy-two children with posterior fossa medulloblastoma were diagnosed at the Hospital for Sick Children, Toronto, from 1977 to 1987 and treated by standard methods. The 5- and 10-year survival and disease-free survival rates were 71% and 63%, and 64% and 63%, respectively. Total tumor resection, as determined by the surgeon was the most significant favorable prognostic factor. Post-operative meningitis, a residual enhancing mass lesion on the post-operative, pre irradiation CT scan and dissemination to the brain or cord at diagnosis were unfavorable factors. These four easily definable factors were used to define a staging system with prognostic significance. Five-year disease-free survival rates were for Stage I (total resection, no adverse factor) 100%, Stage II (total resection with one or more adverse factor or less than total resection with no other adverse factor) 78%, and Stage III (less than total resection with one or more adverse factor) 18%. Evaluation of treatment results in medulloblastoma requires that these prognostic factors be known.
AB - Seventy-two children with posterior fossa medulloblastoma were diagnosed at the Hospital for Sick Children, Toronto, from 1977 to 1987 and treated by standard methods. The 5- and 10-year survival and disease-free survival rates were 71% and 63%, and 64% and 63%, respectively. Total tumor resection, as determined by the surgeon was the most significant favorable prognostic factor. Post-operative meningitis, a residual enhancing mass lesion on the post-operative, pre irradiation CT scan and dissemination to the brain or cord at diagnosis were unfavorable factors. These four easily definable factors were used to define a staging system with prognostic significance. Five-year disease-free survival rates were for Stage I (total resection, no adverse factor) 100%, Stage II (total resection with one or more adverse factor or less than total resection with no other adverse factor) 78%, and Stage III (less than total resection with one or more adverse factor) 18%. Evaluation of treatment results in medulloblastoma requires that these prognostic factors be known.
KW - Childhood treatment
KW - Medulloblastoma
KW - Prognostic factors
UR - http://www.scopus.com/inward/record.url?scp=0025080493&partnerID=8YFLogxK
U2 - 10.1016/0360-3016(90)90533-P
DO - 10.1016/0360-3016(90)90533-P
M3 - Article
C2 - 2394606
AN - SCOPUS:0025080493
SN - 0360-3016
VL - 19
SP - 265
EP - 274
JO - International Journal of Radiation Oncology, Biology, Physics
JF - International Journal of Radiation Oncology, Biology, Physics
IS - 2
ER -