Postoperative prevention of relapse of Crohn's disease

Anil Keshava, David C. C. Bartolo

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Conclusion: The goal of reducing recurrence after surgery for Crohn's disease is a challenging one. Despite numerous studies, we do not have conclusive evidence of predictors of recurrence; however, data on the risks associated with smoking, particularly in females, have accumulated and it is appropriate to advise patients that smoking increases the risk not only of developing Crohn's disease but also of disease recurrence. Recent studies suggest that 5-ASA confers only a small benefit at doses between 2.4 and 3 g/day in patients undergoing ileocolic resection; the long-term role of this drug is uncertain. The oral steroid budesonide shows some promise in preventing the development of new lesions. Its side-effect profile makes it a candidate for further study but, as yet, there is no firm evidence of its worth in standard preventive management regimens. We feel that RCTs need to be conducted to examine the role of immunomodulator therapy. The limited data available suggests a small therapeutic benefit for this class of drug and further studies are required to validate this.

Original languageEnglish
Title of host publicationInflammatory bowel disease and familial adenomatous polyposis
Subtitle of host publicationclinical management and patients’ quality of life
EditorsGian Gaetano Delaini
Place of PublicationMilan
PublisherSpringer, Springer Nature
Pages211-215
Number of pages5
ISBN (Electronic)9788847004344
ISBN (Print)9788847004337
DOIs
Publication statusPublished - 2006
Externally publishedYes

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