Potential analgesic, anti-inflammatory and antioxidant activities of hydroalcoholic extract of Areca catechu L. nut

Amol M. Bhandare, Ajay D. Kshirsagar*, Neeraj S. Vyawahare, Avinash A. Hadambar, Vrushali S. Thorve

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

86 Citations (Scopus)

Abstract

The hydroalcoholic extract of Areca catechu L. (ANE) nut was screened for its analgesic, anti-inflammatory and in vitro antioxidant potential. Three doses of ANE (250, 500 and 1000mg/kg orally) were tested for analgesic and anti-inflammatory activities. Evaluation of analgesic activity of ANE was performed using hot plate and formalin test in mice. ANE showed maximum increase in hot plate reaction time (56.27%, p<0.01), while reduced the duration of licking/biting behaviors in first (39.45%, p<0.05) and second (92.71%, p<0.01) phases of the formalin test indicating significant analgesic activity. ANE reduced the paw edema considerably (86.79% inhibition after 24h, p<0.01) in dose-dependent manner compared to carrageenan-induced rat. In addition, in vitro antioxidant activity of ANE was investigated by total phenolic content (TPC) and hydrogen peroxide assay. The IC50 observed in hydrogen peroxide assay was 83.14μg/ml and TPC 120.56±21.09mg QE/g. Altogether, these results suggest that the hydroalcoholic extract of Areca catechu could be considered as a potential analgesic, anti-inflammatory and antioxidant agent.

Original languageEnglish
Pages (from-to)3412-3417
Number of pages6
JournalFood and Chemical Toxicology
Volume48
Issue number12
DOIs
Publication statusPublished - Dec 2010

Keywords

  • Analgesic
  • Anti-inflammatory
  • Antioxidant
  • Areca catechu
  • Arecoline

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