Potential role of micro-RNAs in head and neck tumorigenesis

Nham Tran; Christopher J. O'Brien; Jonathan Clark; Barbara Rose

doi:10.1002/hed.21356

Potential role of micro-RNAs in head and neck tumorigenesis

Nham Tran^*, Christopher J. O'Brien, Jonathan Clark, Barbara Rose

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

51 Citations (Scopus)

Abstract

A new class of regulatory molecules known as microRNAs (miRNAs) is redefining our understanding of the molecular pathways associated with tumorigenesis. These miRNAs are small noncoding RNA (ncRNA) sequences with potent regulatory potential. The aberrant expression of miRNAs has been associated with the development of various tumors. It has been suggested that miRNAs can both regulate and act as tumor-suppressor genes and oncogenes. Our understanding of the role of miRNAs in head and neck tumorigenesis is in its infancy. However, several recent studies have revealed extensive dysregulation of miRNA in head and neck tumors and have highlighted the potential of certain miRNAs to act as diagnostic and prognostic markers and targets for new therapeutic agents. The intent of this review is to discuss and summarize current findings that point to a significant role for miRNAs in head and neck tumorigenesis.

Original language	English
Pages (from-to)	1099-1111
Number of pages	13
Journal	Head and Neck
Volume	32
Issue number	8
DOIs	https://doi.org/10.1002/hed.21356
Publication status	Published - Aug 2010
Externally published	Yes

Keywords

Biomarkers
Gene regulation
Head and neck
microRNAs
Oncogenes

Access to Document

10.1002/hed.21356

Cite this

@article{b91e6e2a930f4304b5af86f0a81a96e4,

title = "Potential role of micro-RNAs in head and neck tumorigenesis",

abstract = "A new class of regulatory molecules known as microRNAs (miRNAs) is redefining our understanding of the molecular pathways associated with tumorigenesis. These miRNAs are small noncoding RNA (ncRNA) sequences with potent regulatory potential. The aberrant expression of miRNAs has been associated with the development of various tumors. It has been suggested that miRNAs can both regulate and act as tumor-suppressor genes and oncogenes. Our understanding of the role of miRNAs in head and neck tumorigenesis is in its infancy. However, several recent studies have revealed extensive dysregulation of miRNA in head and neck tumors and have highlighted the potential of certain miRNAs to act as diagnostic and prognostic markers and targets for new therapeutic agents. The intent of this review is to discuss and summarize current findings that point to a significant role for miRNAs in head and neck tumorigenesis.",

keywords = "Biomarkers, Gene regulation, Head and neck, microRNAs, Oncogenes",

author = "Nham Tran and O'Brien, {Christopher J.} and Jonathan Clark and Barbara Rose",

year = "2010",

month = aug,

doi = "10.1002/hed.21356",

language = "English",

volume = "32",

pages = "1099--1111",

journal = "Head and Neck",

issn = "1043-3074",

publisher = "John Wiley & Sons",

number = "8",

}

TY - JOUR

T1 - Potential role of micro-RNAs in head and neck tumorigenesis

AU - Tran, Nham

AU - O'Brien, Christopher J.

AU - Clark, Jonathan

AU - Rose, Barbara

PY - 2010/8

Y1 - 2010/8

N2 - A new class of regulatory molecules known as microRNAs (miRNAs) is redefining our understanding of the molecular pathways associated with tumorigenesis. These miRNAs are small noncoding RNA (ncRNA) sequences with potent regulatory potential. The aberrant expression of miRNAs has been associated with the development of various tumors. It has been suggested that miRNAs can both regulate and act as tumor-suppressor genes and oncogenes. Our understanding of the role of miRNAs in head and neck tumorigenesis is in its infancy. However, several recent studies have revealed extensive dysregulation of miRNA in head and neck tumors and have highlighted the potential of certain miRNAs to act as diagnostic and prognostic markers and targets for new therapeutic agents. The intent of this review is to discuss and summarize current findings that point to a significant role for miRNAs in head and neck tumorigenesis.

AB - A new class of regulatory molecules known as microRNAs (miRNAs) is redefining our understanding of the molecular pathways associated with tumorigenesis. These miRNAs are small noncoding RNA (ncRNA) sequences with potent regulatory potential. The aberrant expression of miRNAs has been associated with the development of various tumors. It has been suggested that miRNAs can both regulate and act as tumor-suppressor genes and oncogenes. Our understanding of the role of miRNAs in head and neck tumorigenesis is in its infancy. However, several recent studies have revealed extensive dysregulation of miRNA in head and neck tumors and have highlighted the potential of certain miRNAs to act as diagnostic and prognostic markers and targets for new therapeutic agents. The intent of this review is to discuss and summarize current findings that point to a significant role for miRNAs in head and neck tumorigenesis.

KW - Biomarkers

KW - Gene regulation

KW - Head and neck

KW - microRNAs

KW - Oncogenes

UR - http://www.scopus.com/inward/record.url?scp=77955605960&partnerID=8YFLogxK

U2 - 10.1002/hed.21356

DO - 10.1002/hed.21356

M3 - Review article

C2 - 20213828

AN - SCOPUS:77955605960

SN - 1043-3074

VL - 32

SP - 1099

EP - 1111

JO - Head and Neck

JF - Head and Neck

IS - 8

ER -

Potential role of micro-RNAs in head and neck tumorigenesis

Abstract

Keywords

Access to Document

Other files and links

Fingerprint

Cite this