Pre-eclampsia

the potential of GSNO reductase inhibitors

Thomas R. Everett*, Ian B. Wilkinson, Christoph C. Lees

*Corresponding author for this work

Research output: Contribution to journalReview article

3 Citations (Scopus)
2 Downloads (Pure)

Abstract

Purpose of Review: Pre-eclampsia remains a leading worldwide cause of maternal death and of perinatal morbidity. There remains no definitive treatment except delivery of the fetus. Recent Findings: Recent insights into the cardiovascular changes that are evident prior to, during, and persist after pre-eclampsia have improved understanding of the underlying pathophysiology—disruption of normal endothelial function and decreased nitric oxide bioavailability. S-nitrosoglutathione (GSNO) is an endogenous S-nitrosothiol that acts as a NO pool and, by replenishing or preventing the breakdown of GSNO, endothelial dysfunction can be ameliorated. GSNO reductase inhibitors are a novel class of drug that can increase NO bioavailability. Summary: GSNO reductase inhibitors have demonstrated improvement of endothelial dysfunction in animal models, and in vivo human studies have shown them to be well tolerated. GSNOR inhibitors offer a potentially promising option for the management of pre-eclampsia.

Original languageEnglish
Article number20
Pages (from-to)1-7
Number of pages7
JournalCurrent Hypertension Reports
Volume19
Issue number3
DOIs
Publication statusPublished - Mar 2017
Externally publishedYes

Bibliographical note

Copyright the Author(s) 2017. Version archived for private and non-commercial use with the permission of the author/s and according to publisher conditions. For further rights please contact the publisher.

Keywords

  • pre-eclampsia
  • S-nitrosoglutathione
  • GSNO
  • GSNO reductase inhibitors

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