Predicting the pattern of regional metastases from cutaneous squamous cell carcinoma of the head and neck based on location of the primary

Ardalan Ebrahimi; Marc D. Moncrieff; Jonathan R. Clark; Kerwin F. Shannon; Kan Gao; Christopher G. Milross; Christopher J. O'Brien

doi:10.1002/hed.21332

Predicting the pattern of regional metastases from cutaneous squamous cell carcinoma of the head and neck based on location of the primary

Ardalan Ebrahimi, Marc D. Moncrieff, Jonathan R. Clark, Kerwin F. Shannon, Kan Gao, Christopher G. Milross, Christopher J. O'Brien

Research output: Contribution to journal › Article › peer-review

47 Citations (Scopus)

Abstract

Background We aimed to analyze the distribution of regional nodal metastases according to primary tumor location in patients with cutaneous squamous cell carcinoma of the head and neck (SCCHN). Methods Analysis of 295 neck dissections performed for patients with clinically evident regional metastases from cutaneous SCCHN between 1987 and 2009. Results Level I involvement in the absence of level II or III only occurred in patients with facial primaries. In patients with clear nodes in level II-III, the risk of level IV-V involvement was 0.0% for external ear primaries, 2.7% for face and anterior scalp, and 15.8% for posterior scalp and neck. Conclusion In patients undergoing parotidectomy for metastatic cutaneous SCCHN with a clinically negative neck, the results of this study support selective neck dissection including level I-III for facial primaries, level II-III for anterior scalp and external ear primaries, and levels II-V for posterior scalp and neck primaries.

Original language	English
Pages (from-to)	1288-1294
Number of pages	7
Journal	Head and Neck
Volume	32
Issue number	10
DOIs	https://doi.org/10.1002/hed.21332
Publication status	Published - Oct 2010
Externally published	Yes

Keywords

cutaneous squamous cell carcinoma
head and neck
lymph nodes
neck dissection
parotid metastasis

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title = "Predicting the pattern of regional metastases from cutaneous squamous cell carcinoma of the head and neck based on location of the primary",

abstract = "Background We aimed to analyze the distribution of regional nodal metastases according to primary tumor location in patients with cutaneous squamous cell carcinoma of the head and neck (SCCHN). Methods Analysis of 295 neck dissections performed for patients with clinically evident regional metastases from cutaneous SCCHN between 1987 and 2009. Results Level I involvement in the absence of level II or III only occurred in patients with facial primaries. In patients with clear nodes in level II-III, the risk of level IV-V involvement was 0.0% for external ear primaries, 2.7% for face and anterior scalp, and 15.8% for posterior scalp and neck. Conclusion In patients undergoing parotidectomy for metastatic cutaneous SCCHN with a clinically negative neck, the results of this study support selective neck dissection including level I-III for facial primaries, level II-III for anterior scalp and external ear primaries, and levels II-V for posterior scalp and neck primaries.",

keywords = "cutaneous squamous cell carcinoma, head and neck, lymph nodes, neck dissection, parotid metastasis",

author = "Ardalan Ebrahimi and Moncrieff, {Marc D.} and Clark, {Jonathan R.} and Shannon, {Kerwin F.} and Kan Gao and Milross, {Christopher G.} and O'Brien, {Christopher J.}",

year = "2010",

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language = "English",

volume = "32",

pages = "1288--1294",

journal = "Head and Neck",

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Predicting the pattern of regional metastases from cutaneous squamous cell carcinoma of the head and neck based on location of the primary. / Ebrahimi, Ardalan; Moncrieff, Marc D.; Clark, Jonathan R.; Shannon, Kerwin F.; Gao, Kan; Milross, Christopher G.; O'Brien, Christopher J.

In: Head and Neck, Vol. 32, No. 10, 10.2010, p. 1288-1294.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Predicting the pattern of regional metastases from cutaneous squamous cell carcinoma of the head and neck based on location of the primary

AU - Ebrahimi, Ardalan

AU - Moncrieff, Marc D.

AU - Clark, Jonathan R.

AU - Shannon, Kerwin F.

AU - Gao, Kan

AU - Milross, Christopher G.

AU - O'Brien, Christopher J.

PY - 2010/10

Y1 - 2010/10

N2 - Background We aimed to analyze the distribution of regional nodal metastases according to primary tumor location in patients with cutaneous squamous cell carcinoma of the head and neck (SCCHN). Methods Analysis of 295 neck dissections performed for patients with clinically evident regional metastases from cutaneous SCCHN between 1987 and 2009. Results Level I involvement in the absence of level II or III only occurred in patients with facial primaries. In patients with clear nodes in level II-III, the risk of level IV-V involvement was 0.0% for external ear primaries, 2.7% for face and anterior scalp, and 15.8% for posterior scalp and neck. Conclusion In patients undergoing parotidectomy for metastatic cutaneous SCCHN with a clinically negative neck, the results of this study support selective neck dissection including level I-III for facial primaries, level II-III for anterior scalp and external ear primaries, and levels II-V for posterior scalp and neck primaries.

AB - Background We aimed to analyze the distribution of regional nodal metastases according to primary tumor location in patients with cutaneous squamous cell carcinoma of the head and neck (SCCHN). Methods Analysis of 295 neck dissections performed for patients with clinically evident regional metastases from cutaneous SCCHN between 1987 and 2009. Results Level I involvement in the absence of level II or III only occurred in patients with facial primaries. In patients with clear nodes in level II-III, the risk of level IV-V involvement was 0.0% for external ear primaries, 2.7% for face and anterior scalp, and 15.8% for posterior scalp and neck. Conclusion In patients undergoing parotidectomy for metastatic cutaneous SCCHN with a clinically negative neck, the results of this study support selective neck dissection including level I-III for facial primaries, level II-III for anterior scalp and external ear primaries, and levels II-V for posterior scalp and neck primaries.

KW - cutaneous squamous cell carcinoma

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KW - lymph nodes

KW - neck dissection

KW - parotid metastasis

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