Prediction of interface residue based on the features of residue interaction network

Xiong Jiao*, Shoba Ranganathan

*Corresponding author for this work

    Research output: Contribution to journalArticlepeer-review

    16 Citations (Scopus)


    Protein-protein interaction plays a crucial role in the cellular biological processes. Interface prediction can improve our understanding of the molecular mechanisms of the related processes and functions. In this work, we propose a classification method to recognize the interface residue based on the features of a weighted residue interaction network. The random forest algorithm is used for the prediction and 16 network parameters and the B-factor are acting as the element of the input feature vector. Compared with other similar work, the method is feasible and effective. The relative importance of these features also be analyzed to identify the key feature for the prediction. Some biological meaning of the important feature is explained. The results of this work can be used for the related work about the structure-function relationship analysis via a residue interaction network model.

    Original languageEnglish
    Pages (from-to)49-54
    Number of pages6
    JournalJournal of Theoretical Biology
    Publication statusPublished - 7 Nov 2017


    • Interface prediction
    • Network feature
    • Protein-protein interaction
    • Random forest


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