Prediction of time trends in recovery of cognitive function after mild head injury

Kay Müller; Tor Ingebrigtsen; Tom Wilsgaard; Gry Wikran; Toril Fagerheim; Bertil Romner; Knut Waterloo

doi:10.1227/01.NEU.0000340978.42892.78

Prediction of time trends in recovery of cognitive function after mild head injury

Kay Müller^*, Tor Ingebrigtsen, Tom Wilsgaard, Gry Wikran, Toril Fagerheim, Bertil Romner, Knut Waterloo

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

43 Citations (Scopus)

Abstract

OBJECTIVE: To investigate relations between predictors and outcomes, and especially to identify predictors influencing the time trend in recovery after mild traumatic brain injury. METHODS: We included 59 patients with mild head injury in a prospective study. They underwent comprehensive assessment with neurological and neuroradiological examinations, serum S-100B analysis, and apolipoprotein E (APOE) genotyping. Neuropsychological testing was performed before and 6 months after discharge. Linear mixed models were used to assess associations between baseline predictors and neurocognitive performance and its change. RESULTS: A Glasgow Coma Scale score of less than 15, traumatic brain injury demonstrated with computed tomography, magnetic resonance imaging, and serum S-100B greater than 0.14 μg/L predicted impaired cognitive performance both at baseline and after 6 months; APOE genotype did not. There was significant improvement of performance after 6 months. APOE-ε4 genotype was the only independent factor significantly predicting less improvement. CONCLUSION: The presence of the APOE-ε4 allele predicts less recovery of cognitive function after mild head injury.

Original language	English
Pages (from-to)	698-704
Number of pages	7
Journal	Neurosurgery
Volume	64
Issue number	4
DOIs	https://doi.org/10.1227/01.NEU.0000340978.42892.78
Publication status	Published - Apr 2009
Externally published	Yes

Keywords

Brain trauma
Neuropsychological assessment
Risk factors in epidemiology

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title = "Prediction of time trends in recovery of cognitive function after mild head injury",

abstract = "OBJECTIVE: To investigate relations between predictors and outcomes, and especially to identify predictors influencing the time trend in recovery after mild traumatic brain injury. METHODS: We included 59 patients with mild head injury in a prospective study. They underwent comprehensive assessment with neurological and neuroradiological examinations, serum S-100B analysis, and apolipoprotein E (APOE) genotyping. Neuropsychological testing was performed before and 6 months after discharge. Linear mixed models were used to assess associations between baseline predictors and neurocognitive performance and its change. RESULTS: A Glasgow Coma Scale score of less than 15, traumatic brain injury demonstrated with computed tomography, magnetic resonance imaging, and serum S-100B greater than 0.14 μg/L predicted impaired cognitive performance both at baseline and after 6 months; APOE genotype did not. There was significant improvement of performance after 6 months. APOE-ε4 genotype was the only independent factor significantly predicting less improvement. CONCLUSION: The presence of the APOE-ε4 allele predicts less recovery of cognitive function after mild head injury.",

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AU - Müller, Kay

AU - Ingebrigtsen, Tor

AU - Wilsgaard, Tom

AU - Wikran, Gry

AU - Fagerheim, Toril

AU - Romner, Bertil

AU - Waterloo, Knut

PY - 2009/4

Y1 - 2009/4

N2 - OBJECTIVE: To investigate relations between predictors and outcomes, and especially to identify predictors influencing the time trend in recovery after mild traumatic brain injury. METHODS: We included 59 patients with mild head injury in a prospective study. They underwent comprehensive assessment with neurological and neuroradiological examinations, serum S-100B analysis, and apolipoprotein E (APOE) genotyping. Neuropsychological testing was performed before and 6 months after discharge. Linear mixed models were used to assess associations between baseline predictors and neurocognitive performance and its change. RESULTS: A Glasgow Coma Scale score of less than 15, traumatic brain injury demonstrated with computed tomography, magnetic resonance imaging, and serum S-100B greater than 0.14 μg/L predicted impaired cognitive performance both at baseline and after 6 months; APOE genotype did not. There was significant improvement of performance after 6 months. APOE-ε4 genotype was the only independent factor significantly predicting less improvement. CONCLUSION: The presence of the APOE-ε4 allele predicts less recovery of cognitive function after mild head injury.

AB - OBJECTIVE: To investigate relations between predictors and outcomes, and especially to identify predictors influencing the time trend in recovery after mild traumatic brain injury. METHODS: We included 59 patients with mild head injury in a prospective study. They underwent comprehensive assessment with neurological and neuroradiological examinations, serum S-100B analysis, and apolipoprotein E (APOE) genotyping. Neuropsychological testing was performed before and 6 months after discharge. Linear mixed models were used to assess associations between baseline predictors and neurocognitive performance and its change. RESULTS: A Glasgow Coma Scale score of less than 15, traumatic brain injury demonstrated with computed tomography, magnetic resonance imaging, and serum S-100B greater than 0.14 μg/L predicted impaired cognitive performance both at baseline and after 6 months; APOE genotype did not. There was significant improvement of performance after 6 months. APOE-ε4 genotype was the only independent factor significantly predicting less improvement. CONCLUSION: The presence of the APOE-ε4 allele predicts less recovery of cognitive function after mild head injury.

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JO - Neurosurgery

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Prediction of time trends in recovery of cognitive function after mild head injury

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Keywords

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