TY - JOUR
T1 - Predictors of good visual recovery in patients with spontaneously resolved acute CSCR
T2 - MICRoN Report number thirteen
AU - Hasan, Nasiq
AU - Sahoo, Niroj
AU - Gidwani, Korrina
AU - Saju, Stanley
AU - Cao, Jessica
AU - Wykoff, Charles C.
AU - Shah, Priya
AU - Singhanetr, Panisa
AU - Rossin, Elizabeth
AU - Ashfaq, Yusuf
AU - Kroeger, Zachary
AU - Gregori, Giulia
AU - Lupidi, Marco
AU - Trisolini, Carol Iveth Villafuerte
AU - Yiu, Glenn
AU - Momanaei, Bita
AU - Ni, Roselind
AU - Garg, Sunir
AU - Imanaga, Naoya
AU - Koizumi, Hideki
AU - Checchin, Lisa
AU - Pili, Lorenzo
AU - Parodi, Maurizio Battaglia
AU - Khateb, Samer
AU - Piccoli, Gabriele
AU - Vujosevic, Stela
AU - Desideri, Lorenzo Ferro
AU - Munk, Marion R.
AU - Winter, Halit
AU - Gill, Manjot K.
AU - Lima, Luiz H.
AU - Fernandez, Carmen Antia Rodriguez
AU - Barquet, Luis Arias
AU - Kim, Min
AU - Lai, Timothy Y. Y.
AU - Fung, Adrian T.
AU - Zhang, Michael
AU - Wu, Lihteh
AU - Chhablani, J. A. Y.
AU - MICRoN Study Group
N1 - Copyright the Author(s) 2026. Version archived for private and non-commercial use with the permission of the author/s and according to publisher conditions. For further rights please contact the publisher.
PY - 2026/5/20
Y1 - 2026/5/20
N2 - Purpose: This study investigated factors that lead to failure to achieve 20/20 visual acuity (VA) in patients with spontaneously-resolved acute CSCR. Design: Multicenter retrospective observational cohort study Methods: In this study, data were collected from 189 patients with first episode, spontaneously resolved acute CSCR in collaboration with the Macula Society CSCR Study Group (MICRoN). Patients were categorized based on post-resolution best-recorded visual acuity (BRVA) as better or worse than 20/20. Demographic characteristics and multimodal imaging features were analyzed to identify pertinent baseline biomarkers. Multivariate logistic regression identified several factors that were associated with <20/20 VA after resolution. Results: This study included 195 eyes (189 patients), of whom 108 eyes (55.38%) achieved ≥20/20 VA and 87 (44.62%) demonstrated <20/20 VA. The mean age of patients was 45.45 ± 10.84 years, and 139 (73.54%) were males. Multivariate logistic regression showed older age (OR = 1.07, 95% CI: 1.03-1.11; P = .001), poor baseline VA (OR = 1.37, 95% CI: 1.15-1.63; p < .001), absence of serous pigment epithelial detachment (PED) (OR = 0.30, 95% CI: 0.09-0.95; P = .040) and bilaterality (OR = 4.12, 95% CI: 1.33-12.74; P = .014) were independent predictors of <20/20 VA post-resolution. Conclusion: Resolution of SRF in acute CSCR does not uniformly translate into 20/20 vision. Older age, poorer baseline BRVA, absence of serous PED, and bilateral CSCR were independent predictors of failure to achieve 20/20 vision after resolution. These findings highlight the importance of careful prognostication and functional assessment in cases of acute, single-episode CSCR.
AB - Purpose: This study investigated factors that lead to failure to achieve 20/20 visual acuity (VA) in patients with spontaneously-resolved acute CSCR. Design: Multicenter retrospective observational cohort study Methods: In this study, data were collected from 189 patients with first episode, spontaneously resolved acute CSCR in collaboration with the Macula Society CSCR Study Group (MICRoN). Patients were categorized based on post-resolution best-recorded visual acuity (BRVA) as better or worse than 20/20. Demographic characteristics and multimodal imaging features were analyzed to identify pertinent baseline biomarkers. Multivariate logistic regression identified several factors that were associated with <20/20 VA after resolution. Results: This study included 195 eyes (189 patients), of whom 108 eyes (55.38%) achieved ≥20/20 VA and 87 (44.62%) demonstrated <20/20 VA. The mean age of patients was 45.45 ± 10.84 years, and 139 (73.54%) were males. Multivariate logistic regression showed older age (OR = 1.07, 95% CI: 1.03-1.11; P = .001), poor baseline VA (OR = 1.37, 95% CI: 1.15-1.63; p < .001), absence of serous pigment epithelial detachment (PED) (OR = 0.30, 95% CI: 0.09-0.95; P = .040) and bilaterality (OR = 4.12, 95% CI: 1.33-12.74; P = .014) were independent predictors of <20/20 VA post-resolution. Conclusion: Resolution of SRF in acute CSCR does not uniformly translate into 20/20 vision. Older age, poorer baseline BRVA, absence of serous PED, and bilateral CSCR were independent predictors of failure to achieve 20/20 vision after resolution. These findings highlight the importance of careful prognostication and functional assessment in cases of acute, single-episode CSCR.
UR - https://www.scopus.com/pages/publications/105041883156
U2 - 10.1016/j.ajo.2026.05.023
DO - 10.1016/j.ajo.2026.05.023
M3 - Article
C2 - 42167433
AN - SCOPUS:105041883156
SN - 0002-9394
VL - 289
SP - 134
EP - 144
JO - American Journal of Ophthalmology
JF - American Journal of Ophthalmology
ER -