Predictors of treatment dropout in self-guided web-based interventions for depression

An 'individual patient data' meta-analysis

E. Karyotaki*, A. Kleiboer, F. Smit, D. T. Turner, A. M. Pastor, G. Andersson, T. Berger, C. Botella, J. M. Breton, P. Carlbring, H. Christensen, E. De Graaf, K. Griffiths, T. Donker, L. Farrer, M. J H Huibers, J. Lenndin, A. Mackinnon, B. Meyer, S. Moritz & 4 others H. Riper, V. Spek, K. Vernmark, P. Cuijpers

*Corresponding author for this work

Research output: Contribution to journalArticle

100 Citations (Scopus)

Abstract

Background It is well known that web-based interventions can be effective treatments for depression. However, dropout rates in web-based interventions are typically high, especially in self-guided web-based interventions. Rigorous empirical evidence regarding factors influencing dropout in self-guided web-based interventions is lacking due to small study sample sizes. In this paper we examined predictors of dropout in an individual patient data meta-analysis to gain a better understanding of who may benefit from these interventions. Method A comprehensive literature search for all randomized controlled trials (RCTs) of psychotherapy for adults with depression from 2006 to January 2013 was conducted. Next, we approached authors to collect the primary data of the selected studies. Predictors of dropout, such as socio-demographic, clinical, and intervention characteristics were examined. Results Data from 2705 participants across ten RCTs of self-guided web-based interventions for depression were analysed. The multivariate analysis indicated that male gender [relative risk (RR) 1.08], lower educational level (primary education, RR 1.26) and co-morbid anxiety symptoms (RR 1.18) significantly increased the risk of dropping out, while for every additional 4 years of age, the risk of dropping out significantly decreased (RR 0.94). Conclusions Dropout can be predicted by several variables and is not randomly distributed. This knowledge may inform tailoring of online self-help interventions to prevent dropout in identified groups at risk.

Original languageEnglish
Pages (from-to)2717-2726
Number of pages10
JournalPsychological Medicine
Volume45
Issue number13
DOIs
Publication statusPublished - 11 Oct 2015
Externally publishedYes

Keywords

  • Adherence
  • depression
  • eHealth
  • self-help
  • treatment
  • treatment dropout
  • web-based interventions

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    Karyotaki, E., Kleiboer, A., Smit, F., Turner, D. T., Pastor, A. M., Andersson, G., ... Cuijpers, P. (2015). Predictors of treatment dropout in self-guided web-based interventions for depression: An 'individual patient data' meta-analysis. Psychological Medicine, 45(13), 2717-2726. https://doi.org/10.1017/S0033291715000665