The Special Issue of User Model User-Adapted International contains articles on personalization for e-health. Camerini and colleagues and Colineau and Paris present work in line with the e-Health stated goal of enabling people to take more control of their healthcare and wellbeing. Colineau and Paris investigate how to motivate members of a family to reflect upon their lifestyle and think of ways to improve it. They use the framework of an online portal. Chittaro and colleagues present a system that also personalizes instructions, but this time for medical practitioners in Emergency Medical Services (EMS), when they have to assist disabled patients. Moving towards decision support as opposed to information provision, Lindgren, in her paper, describes a clinical decision support system to assist medical personnel in the diagnosis of dementia. All the papers of this special issue thus address different aspects of e-Health, all with personalization as a basis for support, whether to patients or medical practitioners.