Preparation and characterization of electrospun PLGA/gelatin nanofibers as a potential drug delivery system

Z. X. Meng, X. X. Xu, W. Zheng, H. M. Zhou, L. Li, Y. F. Zheng*, X. Lou

*Corresponding author for this work

Research output: Contribution to journalArticle

133 Citations (Scopus)

Abstract

Drug (Fenbufen, FBF)-loaded poly(d,. l-lactide-co-glycolide) (PLGA) and PLGA/gelatin nanofibrous scaffolds were fabricated via electrospinning technique. The influences of gelatin content, fiber arrangement, crosslinking time and pH value of the buffer solution on FBF release behavior of the resulting nanofibrous scaffolds were investigated, with the corresponding FBF-loaded PLGA and PLGA/gelatin solvent-cast films as controls. The release rate of FBF was found to be increased with the increment of gelatin content for all the composite samples, and the FBF release rate of aligned nanofibrous scaffold was lower than that of randomly oriented scaffold. Moreover, the crosslinking treatment depressed effectively the burst release of FBF at initial release stage of PLGA/gelatin (9/1) nanofibrous scaffold. In addition, the pH value of the buffer solution could change the physical state of the polymer and affect the FBF release rate.

Original languageEnglish
Pages (from-to)97-102
Number of pages6
JournalColloids and Surfaces B: Biointerfaces
Volume84
Issue number1
DOIs
Publication statusPublished - 1 May 2011
Externally publishedYes

Keywords

  • Drug delivery
  • Electrospinning
  • Gelatin
  • PLGA
  • Scaffold

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