Preparation and evaluation of single and co-engineered combination inhalation carrier formulations for the treatment of asthma

Daniela Traini, Handoko Adi, Oliver K. Valet, Paul M. Young

Research output: Contribution to journalArticlepeer-review

4 Citations (Scopus)

Abstract

Two combination dry powder inhalation formulations were engineered via spray drying and co-spray drying salbutamol base (SB) and beclomethasone dipropionate (BDP). The aerosol performances of the individual drugs, a physical mix and the co-spray-dried particle systems were investigated after blending with conventional lactose carrier, under realistic dose regimes. Furthermore, each system was evaluated in terms of the physicochemical properties and via high-throughput Raman microscopy (to study co-association and deposition patterns after in vitro aerosolisation studies). In general, analysis of the aerosol performance (measured using a next-generation impactor) of the single drug and physical mix formulations suggested that SB and BDP have significantly different stage-deposition profiles. Such observations were further substantiated by scanning electron microscopy, where SB–BDP agglomeration could be observed in the physical mix. Stage deposition from the SB–BDP co-spray-dried powders were different than that for the physical mix, wherein the amount of SB and BDP on each stage was equivalent; suggesting that the two drugs could be targeted and deposited at the same location on the lung epithelia. Raman microscopy of the physical mix and co-spray-dried formulations also confirmed the differences in stage deposition between formulations and co-localised deposition for the co-spray-dried formulation.
Original languageEnglish
Pages (from-to)4267-4276
Number of pages10
JournalJournal of Pharmaceutical Sciences
Volume101
Issue number11
DOIs
Publication statusPublished - 2012
Externally publishedYes

Keywords

  • combination formulations
  • beclomethasone
  • salbutamol
  • Raman spectroscopy
  • in vitro deposition
  • dry powder inhaler
  • aerosol
  • pulmonary drug delivery
  • Formulation
  • powder technology

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