Preparative HPLC with ultrastable-Y zeolite for compound-specific carbon isotopic analyses

Fabien Kenig*, Brian N. Popp, Roger E. Summons

*Corresponding author for this work

    Research output: Contribution to journalArticlepeer-review

    15 Citations (Scopus)


    Preparative high pressure liquid chromatography on US-Y zeolite shape-selective molecular sieve was studied for carbon isotopic fractionation effects. We tested a standard mixture [17β, 21β(H)-hopane, 5α-cholestane] and complex natural hydrocarbon mixtures dominated by tetra- and pentacyclic triterpenoids extracted from Oxford Clay shales. We confirmed that steroids and hopanoids were separated on the basis of stereochemical configuration while isotopic analysis of eluents indicated that shape-selective chromatography did not result in isotopic fractionation. US-Y zeolite chromatography can be used to simplify hydrocarbon mixtures and prepare well resolved mixtures of molecular fossils for compound-specific isotopic analyses (CSIA). (C) 2000 Elsevier Science Ltd.

    Original languageEnglish
    Pages (from-to)1087-1094
    Number of pages8
    JournalOrganic Geochemistry
    Issue number11
    Publication statusPublished - Nov 2000


    • Biomarkers
    • Compound specific isotope analysis
    • Isotope chromatographic effect
    • Liquid chromatography
    • Oxford Clay
    • Zeolite


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