Prevalence and burden of chronic bronchitis symptoms: results from the BOLD study

Filip Mejza; Louisa Gnatiuc; A. Sonia Buist; William M. Vollmer; Bernd Lamprecht; Daniel O. Obaseki; Pawel Nastalek; Ewa Nizankowska-Mogilnicka; Peter G. J. Burney; the BOLD collaborators

doi:10.1183/13993003.00621-2017

Prevalence and burden of chronic bronchitis symptoms: results from the BOLD study

Filip Mejza^*, Louisa Gnatiuc, A. Sonia Buist, William M. Vollmer, Bernd Lamprecht, Daniel O. Obaseki, Pawel Nastalek, Ewa Nizankowska-Mogilnicka, Peter G. J. Burney, the BOLD collaborators

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

79 Citations (Scopus)

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Abstract

We studied the prevalence, burden and potential risk factors for chronic bronchitis symptoms in the Burden of Obstructive Lung Disease study. Representative population-based samples of adults aged ≥40 years were selected in participating sites. Participants completed questionnaires and spirometry. Chronic bronchitis symptoms were defined as chronic cough and phlegm on most days for ≥3 months each year for ≥2 years. Data from 24855 subjects from 33 sites in 29 countries were analysed. There were significant differences in the prevalence of self-reported symptoms meeting our definition of chronic bronchitis across sites, from 10.8% in Lexington (KY, USA), to 0% in Ile-Ife (Nigeria) and Blantyre (Malawi). Older age, less education, current smoking, occupational exposure to fumes, self-reported diagnosis of asthma or lung cancer and family history of chronic lung disease were all associated with increased risk of chronic bronchitis. Chronic bronchitis symptoms were associated with worse lung function, more dyspnoea, increased risk of respiratory exacerbations and reduced quality of life, independent of the presence of other lung diseases. The prevalence of chronic bronchitis symptoms varied widely across the studied sites. Chronic bronchitis symptoms were associated with significant burden both in individuals with chronic airflow obstruction and those with normal lung function.

Original language	English
Article number	1700621
Pages (from-to)	1-10
Number of pages	10
Journal	European Respiratory Journal
Volume	50
Issue number	5
DOIs	https://doi.org/10.1183/13993003.00621-2017
Publication status	Published - 1 Nov 2017
Externally published	Yes

Bibliographical note

Copyright the ERS 2017. Version archived for private and non-commercial use with the permission of the author/s and according to publisher conditions. For further rights please contact the publisher.

Access to Document

10.1183/13993003.00621-2017Licence: CC BY

Publisher version (open access)Final published version, 373 KBLicence: CC BY

Cite this

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title = "Prevalence and burden of chronic bronchitis symptoms: results from the BOLD study",

abstract = "We studied the prevalence, burden and potential risk factors for chronic bronchitis symptoms in the Burden of Obstructive Lung Disease study. Representative population-based samples of adults aged ≥40 years were selected in participating sites. Participants completed questionnaires and spirometry. Chronic bronchitis symptoms were defined as chronic cough and phlegm on most days for ≥3 months each year for ≥2 years. Data from 24855 subjects from 33 sites in 29 countries were analysed. There were significant differences in the prevalence of self-reported symptoms meeting our definition of chronic bronchitis across sites, from 10.8% in Lexington (KY, USA), to 0% in Ile-Ife (Nigeria) and Blantyre (Malawi). Older age, less education, current smoking, occupational exposure to fumes, self-reported diagnosis of asthma or lung cancer and family history of chronic lung disease were all associated with increased risk of chronic bronchitis. Chronic bronchitis symptoms were associated with worse lung function, more dyspnoea, increased risk of respiratory exacerbations and reduced quality of life, independent of the presence of other lung diseases. The prevalence of chronic bronchitis symptoms varied widely across the studied sites. Chronic bronchitis symptoms were associated with significant burden both in individuals with chronic airflow obstruction and those with normal lung function.",

author = "Filip Mejza and Louisa Gnatiuc and Buist, {A. Sonia} and Vollmer, {William M.} and Bernd Lamprecht and Obaseki, {Daniel O.} and Pawel Nastalek and Ewa Nizankowska-Mogilnicka and Burney, {Peter G. J.} and {the BOLD collaborators} and Zhong, {Nan Shan} and Shengming Liu and Jiachun Lu and Pixin Ran and Dali Wang and Jingping Zheng and Yumin Zhou and Ali Kocaba{\c s} and Attila Hancioglu and Ismail Hanta and Sedat Kuleci and Turkyilmaz, {Ahmet Sinan} and Sema Umut and Turgay Unalan and Michael Studnicka and Torkil Dawes and Lea Schirhofer and Eric Bateman and Anamika Jithoo and Desiree Adams and Edward Barnes and Jasper Freeman and Anton Hayes and Sipho Hlengwa and Christine Johannisen and Mariana Koopman and Innocentia Louw and Ina Ludick and Alta Olckers and Johanna Ryck and Janita Storbeck and Thorarinn Gislason and Bryndis Benedikdtsdottir and Kristin J{\"o}rundsdottir and Lovisa Gudmundsdottir and Sigrun Gudmundsdottir and Gunnar Gundmundsson and Jakub Frey and Rafal Harat and Andrzej Pajak and Wojciech Skucha and Andrzej Szczeklik and Magda Twardowska and Tobias Welte and Isabelle Bodemann and Henning Geldmacher and Alexandra Schweda-Linow and Amund Gulsvik and Tina Endresen and Lene Svendsen and Tan, {Wan C.} and Wen Wang and Mannino, {David M.} and John Cain and Rebecca Copeland and Dana Hazen and Jennifer Methvin and Dantes, {Renato B.} and Lourdes Amarillo and Berratio, {Lakan U.} and Fernandez, {Lenora C.} and Francisco, {Norberto A.} and Garcia, {Gerard S.} and {de Guia}, {Teresita S.} and Idolor, {Luisito F.} and Naval, {Sullian S.} and Thessa Reyes and Roa, {Camilo C.} and Sanchez, {Ma Flordeliza} and Simpao, {Leander P.} and Christine Jenkins and Guy Marks and Tessa Bird and Paola Espinel and Kate Hardaker and Brett Toelle and Caron Amor and James Potts and Michael Tumilty and Fiona McLean and Wouters, {Emiel F.M.} and Wesseling, {Geert Jan} and Cristina B{\'a}rbara and F{\'a}tima Rodrigues and Herm{\'i}nia Dias and Jo{\~a}o Cardoso and Jo{\~a}o Almeida and Matos, {Maria Jo{\~a}o} and Paula Sim{\~a}o and Moutinho Santos and Reis Ferreira and Christer Janson and Olafsdottir, {Inga Sif} and Katarina Nisser and Ulrike Spetz-Nystr{\"o}m and Gunilla H{\"a}gg and Lund, {Gun Marie} and Rain J{\~o}gi and Hendrik Laja and Katrin Ulst and Vappu Zobel and Lill, {Toomas Julius} and Koul, {Parvaiz A.} and Sajjad Malik and Hakim, {Nissar A.} and Khan, {Umar Hafiz} and Rohini Chowgule and Vasant Shetye and Jonelle Raphael and Rosel Almeda and Mahesh Tawde and Rafiq Tadvi and Sunil Katkar and Milind Kadam and Rupesh Dhanawade and Umesh Ghurup and Imed Harrabi and Myriam Denguezli and Zouhair Tabka and Hager Daldoul and Zaki Boukheroufa and Firas Chouikha and Khalifa, {Wahbi Belhaj} and Idolor, {Luisito F.} and {de Guia}, {Teresita S.} and Francisco, {Norberto A.} and Roa, {Camilo C.} and Ayuyao, {Fernando G.} and Tady, {Cecil Z.} and Tan, {Daniel T.} and Sylvia Banal-Yang and Balanag, {Vincent M.} and Reyes, {Maria Teresita N.} and Sanjay Juvekar and Siddhi Hirve and Somnath Sambhudas and Bharat Chaidhary and Meera Tambe and Savita Pingale and Arati Umap and Archana Umap and Nitin Shelar and Sampada Devchakke and Sharda Chaudhary and Suvarna Bondre and Savita Walke and Ashleshsa Gawhane and Anil Sapkal and Rupali Argade and Vijay Gaikwad and Sundeep Salvi and Bill Brashier and Jyoti Londhe and Sapna Madas and Benjelloun, {Mohamed C.} and Chakib Nejjari and Mohamed Elbiaze and Rhazi, {Karima El} and Gregory Erhabor and Olayemi Awopeju and Olufemi Adewole and {Al Ghobain}, Mohamed and Hassan Alorainy and Esam El-Hamad and {Al Hajjaj}, Mohamed and Ayan Hashi and Rowena Dela and Rofel Fanuncio and Elizabeth Doloriel and Imelda Marciano and Lyla Safia and Sooronbaev, {Talant M.} and Estebesova, {Bermet M.} and Meerim Akmatalieva and Saadat Usenbaeva and Jypara Kydyrova and Eliza Bostonova and Ulan Sheraliev and Nuridin Marajapov and Nurgul Toktogulova and Berik Emilov and Toktogul Azilova and Gulnara Beishekeeva and Nasyikat Dononbaeva and Aijamal Tabyshova and Kevin Mortimer and Wezzie Nyapigoti and Ernest Mwangoka and Mayamiko Kambwili and Martha Chipeta and Gloria Banda and Suzgo Mkandawire and Justice Banda and Hasan Hafizi and Anila Aliko and Donika Bardhi and Holta Tafa and Natasha Thanasi and Arian Mezini and Alma Teferici and Dafina Todri and Jolanda Nikolla and Rezarta Kazasi and Cherkaski, {Hamid Hacene} and Amira Bengrait and Tabarek Haddad and Ibtissem Zgaoula and Maamar Ghit and Abdelhamid Roubhia and Soumaya Boudra and Feryal Atoui and Randa Yakoubi and Rachid Benali and Abdelghani Bencheikh and Nadia Ait-Khaled and Loh, {Li Cher} and Abdul Rashid and Siti Sholehah and Herve Lawin and Arsene Kpangon and Karl Kpossou and Gildas Agodokpessi and Paul Ayelo and Benjamin Fayomi",

note = "Copyright the ERS 2017. Version archived for private and non-commercial use with the permission of the author/s and according to publisher conditions. For further rights please contact the publisher.",

year = "2017",

month = nov,

day = "1",

doi = "10.1183/13993003.00621-2017",

language = "English",

volume = "50",

pages = "1--10",

journal = "European Respiratory Journal",

issn = "0903-1936",

publisher = "European Respiratory Society",

number = "5",

}

TY - JOUR

T1 - Prevalence and burden of chronic bronchitis symptoms

T2 - results from the BOLD study

AU - Mejza, Filip

AU - Gnatiuc, Louisa

AU - Buist, A. Sonia

AU - Vollmer, William M.

AU - Lamprecht, Bernd

AU - Obaseki, Daniel O.

AU - Nastalek, Pawel

AU - Nizankowska-Mogilnicka, Ewa

AU - Burney, Peter G. J.

AU - the BOLD collaborators

AU - Zhong, Nan Shan

AU - Liu, Shengming

AU - Lu, Jiachun

AU - Ran, Pixin

AU - Wang, Dali

AU - Zheng, Jingping

AU - Zhou, Yumin

AU - Kocabaş, Ali

AU - Hancioglu, Attila

AU - Hanta, Ismail

AU - Kuleci, Sedat

AU - Turkyilmaz, Ahmet Sinan

AU - Umut, Sema

AU - Unalan, Turgay

AU - Studnicka, Michael

AU - Dawes, Torkil

AU - Schirhofer, Lea

AU - Bateman, Eric

AU - Jithoo, Anamika

AU - Adams, Desiree

AU - Barnes, Edward

AU - Freeman, Jasper

AU - Hayes, Anton

AU - Hlengwa, Sipho

AU - Johannisen, Christine

AU - Koopman, Mariana

AU - Louw, Innocentia

AU - Ludick, Ina

AU - Olckers, Alta

AU - Ryck, Johanna

AU - Storbeck, Janita

AU - Gislason, Thorarinn

AU - Benedikdtsdottir, Bryndis

AU - Jörundsdottir, Kristin

AU - Gudmundsdottir, Lovisa

AU - Gudmundsdottir, Sigrun

AU - Gundmundsson, Gunnar

AU - Frey, Jakub

AU - Harat, Rafal

AU - Pajak, Andrzej

AU - Skucha, Wojciech

AU - Szczeklik, Andrzej

AU - Twardowska, Magda

AU - Welte, Tobias

AU - Bodemann, Isabelle

AU - Geldmacher, Henning

AU - Schweda-Linow, Alexandra

AU - Gulsvik, Amund

AU - Endresen, Tina

AU - Svendsen, Lene

AU - Tan, Wan C.

AU - Wang, Wen

AU - Mannino, David M.

AU - Cain, John

AU - Copeland, Rebecca

AU - Hazen, Dana

AU - Methvin, Jennifer

AU - Dantes, Renato B.

AU - Amarillo, Lourdes

AU - Berratio, Lakan U.

AU - Fernandez, Lenora C.

AU - Francisco, Norberto A.

AU - Garcia, Gerard S.

AU - de Guia, Teresita S.

AU - Idolor, Luisito F.

AU - Naval, Sullian S.

AU - Reyes, Thessa

AU - Roa, Camilo C.

AU - Sanchez, Ma Flordeliza

AU - Simpao, Leander P.

AU - Jenkins, Christine

AU - Marks, Guy

AU - Bird, Tessa

AU - Espinel, Paola

AU - Hardaker, Kate

AU - Toelle, Brett

AU - Amor, Caron

AU - Potts, James

AU - Tumilty, Michael

AU - McLean, Fiona

AU - Wouters, Emiel F.M.

AU - Wesseling, Geert Jan

AU - Bárbara, Cristina

AU - Rodrigues, Fátima

AU - Dias, Hermínia

AU - Cardoso, João

AU - Almeida, João

AU - Matos, Maria João

AU - Simão, Paula

AU - Santos, Moutinho

AU - Ferreira, Reis

AU - Janson, Christer

AU - Olafsdottir, Inga Sif

AU - Nisser, Katarina

AU - Spetz-Nyström, Ulrike

AU - Hägg, Gunilla

AU - Lund, Gun Marie

AU - Jõgi, Rain

AU - Laja, Hendrik

AU - Ulst, Katrin

AU - Zobel, Vappu

AU - Lill, Toomas Julius

AU - Koul, Parvaiz A.

AU - Malik, Sajjad

AU - Hakim, Nissar A.

AU - Khan, Umar Hafiz

AU - Chowgule, Rohini

AU - Shetye, Vasant

AU - Raphael, Jonelle

AU - Almeda, Rosel

AU - Tawde, Mahesh

AU - Tadvi, Rafiq

AU - Katkar, Sunil

AU - Kadam, Milind

AU - Dhanawade, Rupesh

AU - Ghurup, Umesh

AU - Harrabi, Imed

AU - Denguezli, Myriam

AU - Tabka, Zouhair

AU - Daldoul, Hager

AU - Boukheroufa, Zaki

AU - Chouikha, Firas

AU - Khalifa, Wahbi Belhaj

AU - Idolor, Luisito F.

AU - de Guia, Teresita S.

AU - Francisco, Norberto A.

AU - Roa, Camilo C.

AU - Ayuyao, Fernando G.

AU - Tady, Cecil Z.

AU - Tan, Daniel T.

AU - Banal-Yang, Sylvia

AU - Balanag, Vincent M.

AU - Reyes, Maria Teresita N.

AU - Juvekar, Sanjay

AU - Hirve, Siddhi

AU - Sambhudas, Somnath

AU - Chaidhary, Bharat

AU - Tambe, Meera

AU - Pingale, Savita

AU - Umap, Arati

AU - Umap, Archana

AU - Shelar, Nitin

AU - Devchakke, Sampada

AU - Chaudhary, Sharda

AU - Bondre, Suvarna

AU - Walke, Savita

AU - Gawhane, Ashleshsa

AU - Sapkal, Anil

AU - Argade, Rupali

AU - Gaikwad, Vijay

AU - Salvi, Sundeep

AU - Brashier, Bill

AU - Londhe, Jyoti

AU - Madas, Sapna

AU - Benjelloun, Mohamed C.

AU - Nejjari, Chakib

AU - Elbiaze, Mohamed

AU - Rhazi, Karima El

AU - Erhabor, Gregory

AU - Awopeju, Olayemi

AU - Adewole, Olufemi

AU - Al Ghobain, Mohamed

AU - Alorainy, Hassan

AU - El-Hamad, Esam

AU - Al Hajjaj, Mohamed

AU - Hashi, Ayan

AU - Dela, Rowena

AU - Fanuncio, Rofel

AU - Doloriel, Elizabeth

AU - Marciano, Imelda

AU - Safia, Lyla

AU - Sooronbaev, Talant M.

AU - Estebesova, Bermet M.

AU - Akmatalieva, Meerim

AU - Usenbaeva, Saadat

AU - Kydyrova, Jypara

AU - Bostonova, Eliza

AU - Sheraliev, Ulan

AU - Marajapov, Nuridin

AU - Toktogulova, Nurgul

AU - Emilov, Berik

AU - Azilova, Toktogul

AU - Beishekeeva, Gulnara

AU - Dononbaeva, Nasyikat

AU - Tabyshova, Aijamal

AU - Mortimer, Kevin

AU - Nyapigoti, Wezzie

AU - Mwangoka, Ernest

AU - Kambwili, Mayamiko

AU - Chipeta, Martha

AU - Banda, Gloria

AU - Mkandawire, Suzgo

AU - Banda, Justice

AU - Hafizi, Hasan

AU - Aliko, Anila

AU - Bardhi, Donika

AU - Tafa, Holta

AU - Thanasi, Natasha

AU - Mezini, Arian

AU - Teferici, Alma

AU - Todri, Dafina

AU - Nikolla, Jolanda

AU - Kazasi, Rezarta

AU - Cherkaski, Hamid Hacene

AU - Bengrait, Amira

AU - Haddad, Tabarek

AU - Zgaoula, Ibtissem

AU - Ghit, Maamar

AU - Roubhia, Abdelhamid

AU - Boudra, Soumaya

AU - Atoui, Feryal

AU - Yakoubi, Randa

AU - Benali, Rachid

AU - Bencheikh, Abdelghani

AU - Ait-Khaled, Nadia

AU - Loh, Li Cher

AU - Rashid, Abdul

AU - Sholehah, Siti

AU - Lawin, Herve

AU - Kpangon, Arsene

AU - Kpossou, Karl

AU - Agodokpessi, Gildas

AU - Ayelo, Paul

AU - Fayomi, Benjamin

N1 - Copyright the ERS 2017. Version archived for private and non-commercial use with the permission of the author/s and according to publisher conditions. For further rights please contact the publisher.

PY - 2017/11/1

Y1 - 2017/11/1

N2 - We studied the prevalence, burden and potential risk factors for chronic bronchitis symptoms in the Burden of Obstructive Lung Disease study. Representative population-based samples of adults aged ≥40 years were selected in participating sites. Participants completed questionnaires and spirometry. Chronic bronchitis symptoms were defined as chronic cough and phlegm on most days for ≥3 months each year for ≥2 years. Data from 24855 subjects from 33 sites in 29 countries were analysed. There were significant differences in the prevalence of self-reported symptoms meeting our definition of chronic bronchitis across sites, from 10.8% in Lexington (KY, USA), to 0% in Ile-Ife (Nigeria) and Blantyre (Malawi). Older age, less education, current smoking, occupational exposure to fumes, self-reported diagnosis of asthma or lung cancer and family history of chronic lung disease were all associated with increased risk of chronic bronchitis. Chronic bronchitis symptoms were associated with worse lung function, more dyspnoea, increased risk of respiratory exacerbations and reduced quality of life, independent of the presence of other lung diseases. The prevalence of chronic bronchitis symptoms varied widely across the studied sites. Chronic bronchitis symptoms were associated with significant burden both in individuals with chronic airflow obstruction and those with normal lung function.

AB - We studied the prevalence, burden and potential risk factors for chronic bronchitis symptoms in the Burden of Obstructive Lung Disease study. Representative population-based samples of adults aged ≥40 years were selected in participating sites. Participants completed questionnaires and spirometry. Chronic bronchitis symptoms were defined as chronic cough and phlegm on most days for ≥3 months each year for ≥2 years. Data from 24855 subjects from 33 sites in 29 countries were analysed. There were significant differences in the prevalence of self-reported symptoms meeting our definition of chronic bronchitis across sites, from 10.8% in Lexington (KY, USA), to 0% in Ile-Ife (Nigeria) and Blantyre (Malawi). Older age, less education, current smoking, occupational exposure to fumes, self-reported diagnosis of asthma or lung cancer and family history of chronic lung disease were all associated with increased risk of chronic bronchitis. Chronic bronchitis symptoms were associated with worse lung function, more dyspnoea, increased risk of respiratory exacerbations and reduced quality of life, independent of the presence of other lung diseases. The prevalence of chronic bronchitis symptoms varied widely across the studied sites. Chronic bronchitis symptoms were associated with significant burden both in individuals with chronic airflow obstruction and those with normal lung function.

UR - http://www.scopus.com/inward/record.url?scp=85049432948&partnerID=8YFLogxK

U2 - 10.1183/13993003.00621-2017

DO - 10.1183/13993003.00621-2017

M3 - Article

C2 - 29167298

AN - SCOPUS:85049432948

SN - 0903-1936

VL - 50

SP - 1

EP - 10

JO - European Respiratory Journal

JF - European Respiratory Journal

IS - 5

M1 - 1700621

ER -

Prevalence and burden of chronic bronchitis symptoms: results from the BOLD study

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