Prevalence and characteristics of adults with preserved ratio impaired spirometry (PRISm): data from the BOLD Australia study

Yijun Zhou; Maria R. Ampon; Michael J. Abramson; Alan L. James; Graeme P. Maguire; Richard Wood-Baker; David P. Johns; Guy B. Marks; Helen K. Reddel; Brett G. Toelle

doi:10.1177/14799731241312687

Prevalence and characteristics of adults with preserved ratio impaired spirometry (PRISm): data from the BOLD Australia study

Yijun Zhou, Maria R. Ampon, Michael J. Abramson, Alan L. James, Graeme P. Maguire, Richard Wood-Baker, David P. Johns, Guy B. Marks, Helen K. Reddel, Brett G. Toelle^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

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Abstract

Background: Individuals with Preserved Ratio Impaired Spirometry (PRISm), defined as FEV₁/FVC ≥0.7 and FEV1 <80% predicted, are at higher risk of developing COPD. However, data for Australian adults are limited. We aimed to describe prevalence of PRISm and its relationship with clinical characteristics in Australia. Method: Data from the Burden of Lung Disease (BOLD) Australia study of randomly selected adults aged ≥40 years from six sites was classified into airflow limitation, PRISm, or normal spirometry groups. Demographic, clinical characteristics, and lung function were compared between groups. Results: Of the study sample (n = 3518), 387 (11%) had PRISm, 549 (15.6%) had airflow limitation, and 2582 (73.4%) had normal spirometry. PRISm was more common in Indigenous Australian adults. Adults with PRISm had more frequent respiratory symptoms, more comorbidities, greater health burden and poorer quality of life than those with normal spirometry. Pre- and post-bronchodilator FEV₁ and FVC were lower in adults with PRISm than those with airflow limitation. Adults with PRISm were less likely to use respiratory medicine than those with airflow limitation (OR = 0.56, 95% CI 0.38–0.81). Conclusions: PRISm was present in 11% of adults in this study and they had similar respiratory symptoms and health burden as adults with airflow limitation.

Original language	English
Pages (from-to)	1-11
Number of pages	11
Journal	Chronic Respiratory Disease
Volume	22
DOIs	https://doi.org/10.1177/14799731241312687
Publication status	Published - 1 Jan 2025

Bibliographical note

Copyright the Author(s) 2025. Version archived for private and non-commercial use with the permission of the author/s and according to publisher conditions. For further rights please contact the publisher.

Keywords

burden of obstructive lung disease
Chronic obstructive pulmonary disease
preserved ratio impaired spirometry
spirometry
symptoms

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10.1177/14799731241312687Licence: CC BY-NC

Publisher version (open access)Final published version, 571 KBLicence: CC BY-NC

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@article{12cb73b709e2467285918d6af9882624,

title = "Prevalence and characteristics of adults with preserved ratio impaired spirometry (PRISm): data from the BOLD Australia study",

abstract = "Background: Individuals with Preserved Ratio Impaired Spirometry (PRISm), defined as FEV1/FVC ≥0.7 and FEV1 <80% predicted, are at higher risk of developing COPD. However, data for Australian adults are limited. We aimed to describe prevalence of PRISm and its relationship with clinical characteristics in Australia. Method: Data from the Burden of Lung Disease (BOLD) Australia study of randomly selected adults aged ≥40 years from six sites was classified into airflow limitation, PRISm, or normal spirometry groups. Demographic, clinical characteristics, and lung function were compared between groups. Results: Of the study sample (n = 3518), 387 (11%) had PRISm, 549 (15.6%) had airflow limitation, and 2582 (73.4%) had normal spirometry. PRISm was more common in Indigenous Australian adults. Adults with PRISm had more frequent respiratory symptoms, more comorbidities, greater health burden and poorer quality of life than those with normal spirometry. Pre- and post-bronchodilator FEV1 and FVC were lower in adults with PRISm than those with airflow limitation. Adults with PRISm were less likely to use respiratory medicine than those with airflow limitation (OR = 0.56, 95% CI 0.38–0.81). Conclusions: PRISm was present in 11% of adults in this study and they had similar respiratory symptoms and health burden as adults with airflow limitation.",

keywords = "burden of obstructive lung disease, Chronic obstructive pulmonary disease, preserved ratio impaired spirometry, spirometry, symptoms",

author = "Yijun Zhou and Ampon, {Maria R.} and Abramson, {Michael J.} and James, {Alan L.} and Maguire, {Graeme P.} and Richard Wood-Baker and Johns, {David P.} and Marks, {Guy B.} and Reddel, {Helen K.} and Toelle, {Brett G.}",

note = "Copyright the Author(s) 2025. Version archived for private and non-commercial use with the permission of the author/s and according to publisher conditions. For further rights please contact the publisher.",

year = "2025",

month = jan,

day = "1",

doi = "10.1177/14799731241312687",

language = "English",

volume = "22",

pages = "1--11",

journal = "Chronic Respiratory Disease",

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TY - JOUR

T1 - Prevalence and characteristics of adults with preserved ratio impaired spirometry (PRISm)

T2 - data from the BOLD Australia study

AU - Zhou, Yijun

AU - Ampon, Maria R.

AU - Abramson, Michael J.

AU - James, Alan L.

AU - Maguire, Graeme P.

AU - Wood-Baker, Richard

AU - Johns, David P.

AU - Marks, Guy B.

AU - Reddel, Helen K.

AU - Toelle, Brett G.

N1 - Copyright the Author(s) 2025. Version archived for private and non-commercial use with the permission of the author/s and according to publisher conditions. For further rights please contact the publisher.

PY - 2025/1/1

Y1 - 2025/1/1

N2 - Background: Individuals with Preserved Ratio Impaired Spirometry (PRISm), defined as FEV1/FVC ≥0.7 and FEV1 <80% predicted, are at higher risk of developing COPD. However, data for Australian adults are limited. We aimed to describe prevalence of PRISm and its relationship with clinical characteristics in Australia. Method: Data from the Burden of Lung Disease (BOLD) Australia study of randomly selected adults aged ≥40 years from six sites was classified into airflow limitation, PRISm, or normal spirometry groups. Demographic, clinical characteristics, and lung function were compared between groups. Results: Of the study sample (n = 3518), 387 (11%) had PRISm, 549 (15.6%) had airflow limitation, and 2582 (73.4%) had normal spirometry. PRISm was more common in Indigenous Australian adults. Adults with PRISm had more frequent respiratory symptoms, more comorbidities, greater health burden and poorer quality of life than those with normal spirometry. Pre- and post-bronchodilator FEV1 and FVC were lower in adults with PRISm than those with airflow limitation. Adults with PRISm were less likely to use respiratory medicine than those with airflow limitation (OR = 0.56, 95% CI 0.38–0.81). Conclusions: PRISm was present in 11% of adults in this study and they had similar respiratory symptoms and health burden as adults with airflow limitation.

AB - Background: Individuals with Preserved Ratio Impaired Spirometry (PRISm), defined as FEV1/FVC ≥0.7 and FEV1 <80% predicted, are at higher risk of developing COPD. However, data for Australian adults are limited. We aimed to describe prevalence of PRISm and its relationship with clinical characteristics in Australia. Method: Data from the Burden of Lung Disease (BOLD) Australia study of randomly selected adults aged ≥40 years from six sites was classified into airflow limitation, PRISm, or normal spirometry groups. Demographic, clinical characteristics, and lung function were compared between groups. Results: Of the study sample (n = 3518), 387 (11%) had PRISm, 549 (15.6%) had airflow limitation, and 2582 (73.4%) had normal spirometry. PRISm was more common in Indigenous Australian adults. Adults with PRISm had more frequent respiratory symptoms, more comorbidities, greater health burden and poorer quality of life than those with normal spirometry. Pre- and post-bronchodilator FEV1 and FVC were lower in adults with PRISm than those with airflow limitation. Adults with PRISm were less likely to use respiratory medicine than those with airflow limitation (OR = 0.56, 95% CI 0.38–0.81). Conclusions: PRISm was present in 11% of adults in this study and they had similar respiratory symptoms and health burden as adults with airflow limitation.

KW - burden of obstructive lung disease

KW - Chronic obstructive pulmonary disease

KW - preserved ratio impaired spirometry

KW - spirometry

KW - symptoms

UR - http://www.scopus.com/inward/record.url?scp=85216076513&partnerID=8YFLogxK

U2 - 10.1177/14799731241312687

DO - 10.1177/14799731241312687

M3 - Article

C2 - 39844530

AN - SCOPUS:85216076513

SN - 1479-9723

VL - 22

SP - 1

EP - 11

JO - Chronic Respiratory Disease

JF - Chronic Respiratory Disease

ER -

Prevalence and characteristics of adults with preserved ratio impaired spirometry (PRISm): data from the BOLD Australia study

Abstract

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Keywords

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