TY - JOUR
T1 - Prevalence and risk factors of epiretinal membrane in a cohort with cardiovascular disease risk, compared with the Blue Mountains Eye Study
AU - Wang, Sarah B.
AU - Mitchell, Paul
AU - Plant, Adam J. H.
AU - Phan, Kevin
AU - Liew, Gerald
AU - Chiha, Joseph
AU - Thiagalingam, Aravinda
AU - Burlutsky, George
AU - Gopinath, Bamini
PY - 2015/12
Y1 - 2015/12
N2 - Aims To describe the prevalence of idiopathic and secondary epiretinal membranes (ERM) in a clinical cohort (Australian Heart Eye Study, AHES) and compare to the Blue Mountains Eye Study, and to determine whether associations exist between idiopathic ERM and the extent and severity of coronary artery disease (CAD).
Methods The AHES is an observational study that surveyed 1680 participants who presented to a tertiary referral hospital for the evaluation of potential CAD by coronary angiography. Severity and extent of CAD was assessed using three scoring systems: (1) segment/vessel scores, (2) Gensini and (3) extent scores. Two types of ERM were identified: a more severe form, termed ‘preretinal macular fibrosis’ (PMF) in which retinal folds were identified; and a less severe form termed ‘cellophane macular reflex’ (CMR), without visible retinal folds.
Results Overall prevalence of ERM was 7.0% (n=115), with CMR and PMF each 3.5%. 72.7% of ERM cases were idiopathic (no secondary cause identified). Prevalence of PMF, but not CMR, was significantly higher than the corresponding age-standardised prevalence in the baseline Blue Mountains Eye Study (p<0.001). There was no significant association between extent and severity of CAD and idiopathic ERM.
Conclusions This study suggests that cardiovascular disease (specifically severity and extent of CAD) is not associated with ERM. However, there may be a greater prevalence of severe ERM (PMF) in a high cardiovascular risk cohort relative to a population-based cohort.
AB - Aims To describe the prevalence of idiopathic and secondary epiretinal membranes (ERM) in a clinical cohort (Australian Heart Eye Study, AHES) and compare to the Blue Mountains Eye Study, and to determine whether associations exist between idiopathic ERM and the extent and severity of coronary artery disease (CAD).
Methods The AHES is an observational study that surveyed 1680 participants who presented to a tertiary referral hospital for the evaluation of potential CAD by coronary angiography. Severity and extent of CAD was assessed using three scoring systems: (1) segment/vessel scores, (2) Gensini and (3) extent scores. Two types of ERM were identified: a more severe form, termed ‘preretinal macular fibrosis’ (PMF) in which retinal folds were identified; and a less severe form termed ‘cellophane macular reflex’ (CMR), without visible retinal folds.
Results Overall prevalence of ERM was 7.0% (n=115), with CMR and PMF each 3.5%. 72.7% of ERM cases were idiopathic (no secondary cause identified). Prevalence of PMF, but not CMR, was significantly higher than the corresponding age-standardised prevalence in the baseline Blue Mountains Eye Study (p<0.001). There was no significant association between extent and severity of CAD and idiopathic ERM.
Conclusions This study suggests that cardiovascular disease (specifically severity and extent of CAD) is not associated with ERM. However, there may be a greater prevalence of severe ERM (PMF) in a high cardiovascular risk cohort relative to a population-based cohort.
UR - http://www.scopus.com/inward/record.url?scp=84948755184&partnerID=8YFLogxK
U2 - 10.1136/bjophthalmol-2015-306776
DO - 10.1136/bjophthalmol-2015-306776
M3 - Article
C2 - 25953845
AN - SCOPUS:84948755184
SN - 0007-1161
VL - 99
SP - 1601
EP - 1605
JO - British Journal of Ophthalmology
JF - British Journal of Ophthalmology
IS - 12
ER -