Prevalence and type of artefact with spectral domain optical coherence tomography macular ganglion cell imaging in glaucoma surveillance

Mona S. Awadalla, Jude Fitzgerald, Nicholas H. Andrew, Tiger Zhou, Henry Marshall, Ayub Qassim, Mark Hassall, Robert J. Casson, Stuart L. Graham, Paul R. Healey, Ashish Agar, Anna Galanopoulos, Simon Phipps, Angela Chappell, John Landers, Jamie E. Craig

Research output: Contribution to journalArticleResearchpeer-review

Abstract

Purpose: The ganglion cell analysis (GCA) of the CIRRUSTM HD-OCT (Carl Zeiss, Meditec; Dublin, CA) provides measurement of the macular ganglion cell-inner plexiform layer (GCIPL) thickness. This study determined the frequency of scan artefacts and errors in GCIPL imaging in individuals undergoing HD-OCT surveillance for glaucoma. Method: A total of 1439 eyes from 721 subjects enrolled in a prospective study assessing predictors of glaucoma progression underwent macular GCIPL imaging with the CIRRUS HD-OCT at recruitment. The prevalence of acquisition errors, segmentation errors, and co-morbid macular pathology was determined. Results: A total of 87 (6.0%) of the 1439 scans had either acquisition errors, segmentation artefacts, or other macular pathology. The most common co-morbid macular pathology was epiretinal membrane in 2.2% of eyes. Conclusion: The macular GCIPL scan was artefact free in 94% of eyes. However, epiretinal membrane and high myopia can cause scan artefact and should be considered when interpreting the results.

LanguageEnglish
Article numbere0206684
Pages1-9
Number of pages9
JournalPLoS ONE
Volume13
Issue number12
DOIs
Publication statusPublished - 5 Dec 2018

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glaucoma
Optical tomography
tomography
Optical Coherence Tomography
Ganglia
Glaucoma
Artifacts
Pathology
image analysis
Imaging techniques
monitoring
Epiretinal Membrane
eyes
cells
Membranes
Myopia
prospective studies
Prospective Studies

Bibliographical note

Copyright the Author(s) 2018. Version archived for private and non-commercial use with the permission of the author/s and according to publisher conditions. For further rights please contact the publisher.

Cite this

Awadalla, M. S., Fitzgerald, J., Andrew, N. H., Zhou, T., Marshall, H., Qassim, A., ... Craig, J. E. (2018). Prevalence and type of artefact with spectral domain optical coherence tomography macular ganglion cell imaging in glaucoma surveillance. PLoS ONE, 13(12), 1-9. [e0206684]. https://doi.org/10.1371/journal.pone.0206684
Awadalla, Mona S. ; Fitzgerald, Jude ; Andrew, Nicholas H. ; Zhou, Tiger ; Marshall, Henry ; Qassim, Ayub ; Hassall, Mark ; Casson, Robert J. ; Graham, Stuart L. ; Healey, Paul R. ; Agar, Ashish ; Galanopoulos, Anna ; Phipps, Simon ; Chappell, Angela ; Landers, John ; Craig, Jamie E. / Prevalence and type of artefact with spectral domain optical coherence tomography macular ganglion cell imaging in glaucoma surveillance. In: PLoS ONE. 2018 ; Vol. 13, No. 12. pp. 1-9.
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abstract = "Purpose: The ganglion cell analysis (GCA) of the CIRRUSTM HD-OCT (Carl Zeiss, Meditec; Dublin, CA) provides measurement of the macular ganglion cell-inner plexiform layer (GCIPL) thickness. This study determined the frequency of scan artefacts and errors in GCIPL imaging in individuals undergoing HD-OCT surveillance for glaucoma. Method: A total of 1439 eyes from 721 subjects enrolled in a prospective study assessing predictors of glaucoma progression underwent macular GCIPL imaging with the CIRRUS HD-OCT at recruitment. The prevalence of acquisition errors, segmentation errors, and co-morbid macular pathology was determined. Results: A total of 87 (6.0{\%}) of the 1439 scans had either acquisition errors, segmentation artefacts, or other macular pathology. The most common co-morbid macular pathology was epiretinal membrane in 2.2{\%} of eyes. Conclusion: The macular GCIPL scan was artefact free in 94{\%} of eyes. However, epiretinal membrane and high myopia can cause scan artefact and should be considered when interpreting the results.",
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Awadalla, MS, Fitzgerald, J, Andrew, NH, Zhou, T, Marshall, H, Qassim, A, Hassall, M, Casson, RJ, Graham, SL, Healey, PR, Agar, A, Galanopoulos, A, Phipps, S, Chappell, A, Landers, J & Craig, JE 2018, 'Prevalence and type of artefact with spectral domain optical coherence tomography macular ganglion cell imaging in glaucoma surveillance', PLoS ONE, vol. 13, no. 12, e0206684, pp. 1-9. https://doi.org/10.1371/journal.pone.0206684

Prevalence and type of artefact with spectral domain optical coherence tomography macular ganglion cell imaging in glaucoma surveillance. / Awadalla, Mona S.; Fitzgerald, Jude; Andrew, Nicholas H.; Zhou, Tiger; Marshall, Henry; Qassim, Ayub; Hassall, Mark; Casson, Robert J.; Graham, Stuart L.; Healey, Paul R.; Agar, Ashish; Galanopoulos, Anna; Phipps, Simon; Chappell, Angela; Landers, John; Craig, Jamie E.

In: PLoS ONE, Vol. 13, No. 12, e0206684, 05.12.2018, p. 1-9.

Research output: Contribution to journalArticleResearchpeer-review

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T1 - Prevalence and type of artefact with spectral domain optical coherence tomography macular ganglion cell imaging in glaucoma surveillance

AU - Awadalla, Mona S.

AU - Fitzgerald, Jude

AU - Andrew, Nicholas H.

AU - Zhou, Tiger

AU - Marshall, Henry

AU - Qassim, Ayub

AU - Hassall, Mark

AU - Casson, Robert J.

AU - Graham, Stuart L.

AU - Healey, Paul R.

AU - Agar, Ashish

AU - Galanopoulos, Anna

AU - Phipps, Simon

AU - Chappell, Angela

AU - Landers, John

AU - Craig, Jamie E.

N1 - Copyright the Author(s) 2018. Version archived for private and non-commercial use with the permission of the author/s and according to publisher conditions. For further rights please contact the publisher.

PY - 2018/12/5

Y1 - 2018/12/5

N2 - Purpose: The ganglion cell analysis (GCA) of the CIRRUSTM HD-OCT (Carl Zeiss, Meditec; Dublin, CA) provides measurement of the macular ganglion cell-inner plexiform layer (GCIPL) thickness. This study determined the frequency of scan artefacts and errors in GCIPL imaging in individuals undergoing HD-OCT surveillance for glaucoma. Method: A total of 1439 eyes from 721 subjects enrolled in a prospective study assessing predictors of glaucoma progression underwent macular GCIPL imaging with the CIRRUS HD-OCT at recruitment. The prevalence of acquisition errors, segmentation errors, and co-morbid macular pathology was determined. Results: A total of 87 (6.0%) of the 1439 scans had either acquisition errors, segmentation artefacts, or other macular pathology. The most common co-morbid macular pathology was epiretinal membrane in 2.2% of eyes. Conclusion: The macular GCIPL scan was artefact free in 94% of eyes. However, epiretinal membrane and high myopia can cause scan artefact and should be considered when interpreting the results.

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