Prevalence and type of artefact with spectral domain optical coherence tomography macular ganglion cell imaging in glaucoma surveillance

Mona S. Awadalla; Jude Fitzgerald; Nicholas H. Andrew; Tiger Zhou; Henry Marshall; Ayub Qassim; Mark Hassall; Robert J. Casson; Stuart L. Graham; Paul R. Healey; Ashish Agar; Anna Galanopoulos; Simon Phipps; Angela Chappell; John Landers; Jamie E. Craig

doi:10.1371/journal.pone.0206684

Prevalence and type of artefact with spectral domain optical coherence tomography macular ganglion cell imaging in glaucoma surveillance

Mona S. Awadalla^*, Jude Fitzgerald, Nicholas H. Andrew, Tiger Zhou, Henry Marshall, Ayub Qassim, Mark Hassall, Robert J. Casson, Stuart L. Graham, Paul R. Healey, Ashish Agar, Anna Galanopoulos, Simon Phipps, Angela Chappell, John Landers, Jamie E. Craig

^*Corresponding author for this work

Faculty of Medicine, Health and Human Sciences

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Abstract

Purpose: The ganglion cell analysis (GCA) of the CIRRUS^TM HD-OCT (Carl Zeiss, Meditec; Dublin, CA) provides measurement of the macular ganglion cell-inner plexiform layer (GCIPL) thickness. This study determined the frequency of scan artefacts and errors in GCIPL imaging in individuals undergoing HD-OCT surveillance for glaucoma. Method: A total of 1439 eyes from 721 subjects enrolled in a prospective study assessing predictors of glaucoma progression underwent macular GCIPL imaging with the CIRRUS HD-OCT at recruitment. The prevalence of acquisition errors, segmentation errors, and co-morbid macular pathology was determined. Results: A total of 87 (6.0%) of the 1439 scans had either acquisition errors, segmentation artefacts, or other macular pathology. The most common co-morbid macular pathology was epiretinal membrane in 2.2% of eyes. Conclusion: The macular GCIPL scan was artefact free in 94% of eyes. However, epiretinal membrane and high myopia can cause scan artefact and should be considered when interpreting the results.

Original language	English
Article number	e0206684
Pages (from-to)	1-9
Number of pages	9
Journal	PLoS ONE
Volume	13
Issue number	12
DOIs	https://doi.org/10.1371/journal.pone.0206684
Publication status	Published - 5 Dec 2018

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Copyright the Author(s) 2018. Version archived for private and non-commercial use with the permission of the author/s and according to publisher conditions. For further rights please contact the publisher.

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Awadalla, M. S., Fitzgerald, J., Andrew, N. H., Zhou, T., Marshall, H., Qassim, A., Hassall, M., Casson, R. J., Graham, S. L., Healey, P. R., Agar, A., Galanopoulos, A., Phipps, S., Chappell, A., Landers, J., & Craig, J. E. (2018). Prevalence and type of artefact with spectral domain optical coherence tomography macular ganglion cell imaging in glaucoma surveillance. PLoS ONE, 13(12), 1-9. Article e0206684. https://doi.org/10.1371/journal.pone.0206684

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title = "Prevalence and type of artefact with spectral domain optical coherence tomography macular ganglion cell imaging in glaucoma surveillance",

abstract = "Purpose: The ganglion cell analysis (GCA) of the CIRRUSTM HD-OCT (Carl Zeiss, Meditec; Dublin, CA) provides measurement of the macular ganglion cell-inner plexiform layer (GCIPL) thickness. This study determined the frequency of scan artefacts and errors in GCIPL imaging in individuals undergoing HD-OCT surveillance for glaucoma. Method: A total of 1439 eyes from 721 subjects enrolled in a prospective study assessing predictors of glaucoma progression underwent macular GCIPL imaging with the CIRRUS HD-OCT at recruitment. The prevalence of acquisition errors, segmentation errors, and co-morbid macular pathology was determined. Results: A total of 87 (6.0%) of the 1439 scans had either acquisition errors, segmentation artefacts, or other macular pathology. The most common co-morbid macular pathology was epiretinal membrane in 2.2% of eyes. Conclusion: The macular GCIPL scan was artefact free in 94% of eyes. However, epiretinal membrane and high myopia can cause scan artefact and should be considered when interpreting the results.",

author = "Awadalla, {Mona S.} and Jude Fitzgerald and Andrew, {Nicholas H.} and Tiger Zhou and Henry Marshall and Ayub Qassim and Mark Hassall and Casson, {Robert J.} and Graham, {Stuart L.} and Healey, {Paul R.} and Ashish Agar and Anna Galanopoulos and Simon Phipps and Angela Chappell and John Landers and Craig, {Jamie E.}",

note = "Copyright the Author(s) 2018. Version archived for private and non-commercial use with the permission of the author/s and according to publisher conditions. For further rights please contact the publisher.",

year = "2018",

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doi = "10.1371/journal.pone.0206684",

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Awadalla, MS, Fitzgerald, J, Andrew, NH, Zhou, T, Marshall, H, Qassim, A, Hassall, M, Casson, RJ, Graham, SL, Healey, PR, Agar, A, Galanopoulos, A, Phipps, S, Chappell, A, Landers, J & Craig, JE 2018, 'Prevalence and type of artefact with spectral domain optical coherence tomography macular ganglion cell imaging in glaucoma surveillance', PLoS ONE, vol. 13, no. 12, e0206684, pp. 1-9. https://doi.org/10.1371/journal.pone.0206684

TY - JOUR

T1 - Prevalence and type of artefact with spectral domain optical coherence tomography macular ganglion cell imaging in glaucoma surveillance

AU - Awadalla, Mona S.

AU - Fitzgerald, Jude

AU - Andrew, Nicholas H.

AU - Zhou, Tiger

AU - Marshall, Henry

AU - Qassim, Ayub

AU - Hassall, Mark

AU - Casson, Robert J.

AU - Graham, Stuart L.

AU - Healey, Paul R.

AU - Agar, Ashish

AU - Galanopoulos, Anna

AU - Phipps, Simon

AU - Chappell, Angela

AU - Landers, John

AU - Craig, Jamie E.

N1 - Copyright the Author(s) 2018. Version archived for private and non-commercial use with the permission of the author/s and according to publisher conditions. For further rights please contact the publisher.

PY - 2018/12/5

Y1 - 2018/12/5

N2 - Purpose: The ganglion cell analysis (GCA) of the CIRRUSTM HD-OCT (Carl Zeiss, Meditec; Dublin, CA) provides measurement of the macular ganglion cell-inner plexiform layer (GCIPL) thickness. This study determined the frequency of scan artefacts and errors in GCIPL imaging in individuals undergoing HD-OCT surveillance for glaucoma. Method: A total of 1439 eyes from 721 subjects enrolled in a prospective study assessing predictors of glaucoma progression underwent macular GCIPL imaging with the CIRRUS HD-OCT at recruitment. The prevalence of acquisition errors, segmentation errors, and co-morbid macular pathology was determined. Results: A total of 87 (6.0%) of the 1439 scans had either acquisition errors, segmentation artefacts, or other macular pathology. The most common co-morbid macular pathology was epiretinal membrane in 2.2% of eyes. Conclusion: The macular GCIPL scan was artefact free in 94% of eyes. However, epiretinal membrane and high myopia can cause scan artefact and should be considered when interpreting the results.

AB - Purpose: The ganglion cell analysis (GCA) of the CIRRUSTM HD-OCT (Carl Zeiss, Meditec; Dublin, CA) provides measurement of the macular ganglion cell-inner plexiform layer (GCIPL) thickness. This study determined the frequency of scan artefacts and errors in GCIPL imaging in individuals undergoing HD-OCT surveillance for glaucoma. Method: A total of 1439 eyes from 721 subjects enrolled in a prospective study assessing predictors of glaucoma progression underwent macular GCIPL imaging with the CIRRUS HD-OCT at recruitment. The prevalence of acquisition errors, segmentation errors, and co-morbid macular pathology was determined. Results: A total of 87 (6.0%) of the 1439 scans had either acquisition errors, segmentation artefacts, or other macular pathology. The most common co-morbid macular pathology was epiretinal membrane in 2.2% of eyes. Conclusion: The macular GCIPL scan was artefact free in 94% of eyes. However, epiretinal membrane and high myopia can cause scan artefact and should be considered when interpreting the results.

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JF - PLoS ONE

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Prevalence and type of artefact with spectral domain optical coherence tomography macular ganglion cell imaging in glaucoma surveillance

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