Prevalence of benign osseous lesions of the spine and association with spinal pain in the general population in whole body MRI

Richard Kasch, Josephin Scheele, Mark Hancock, André Hofer, Christopher Maher, Robin Bülow, Jörn Lange, Andreas Lahm, Matthias Napp, Georgi Wassilew, Carsten Oliver Schmidt

Research output: Contribution to journalArticleResearchpeer-review

Abstract

Background: Benign osseous lesions of the spine are common but precise population prevalence estimates are lacking. Our study aimed to provide the first population-based prevalence estimates and examine association with back and neck pain. Materials and methods: We used data from the population-based Study of Health in Pomerania (SHIP). Whole-body MRI examinations (1.5 Tesla: T1, T2, and TIRM weightings) were available from 3,259 participants. Readings of the spinal MRI images were conducted according to a standardized protocol by a single reader (JS). The intra-rater reliability was greater than Kappa values of 0.98. Pain measures included the seven-day prevalence of spine pain and neck pain, and average spine pain intensity due to spine pain during the past three months. Results: We found 1,200 (36.8%) participants with at least one osseous lesion (2,080 lesions in total). Osseous lesions were less common in men than in women (35.5% vs 38.9%; P = .06). The prevalence of osseous lesions was highest at L2 in both sexes. The prevalence of osseous lesions increased with age. Up to eight osseous lesions were observed in a single subject. Hemangioma (28%), and lipoma (13%) occurred most often. Sclerosis (1.7%), aneurysmal bone cysts (0.7%), and blastoma (0.3%) were rare. Different osseous lesions occurred more often in combination with each other. The association with back or neck pain was mostly negligible. Conclusion: Osseous lesions are common in the general population but of no clinical relevance for spinal pain. The prevalence of osseous lesions varied strongly across different regions of the spine and was also associated with age and gender. Our population-based data offer new insights and assist in judging the relevance of osseous lesions observed on MRIs of patients.

LanguageEnglish
Article numbere0219846
Pages1-15
Number of pages15
JournalPLoS ONE
Volume14
Issue number9
DOIs
Publication statusPublished - 1 Jan 2019

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spine (bones)
lesions (animal)
Magnetic resonance imaging
pain
Spine
Pain
Neck Pain
Population
Back Pain
Bone
neck
Health
Aneurysmal Bone Cysts
back (body region)
Lipoma
Sclerosis
Hemangioma
Reading
lipoma
hemangioma

Bibliographical note

Copyright the Author(s) 2019. Version archived for private and non-commercial use with the permission of the author/s and according to publisher conditions. For further rights please contact the publisher.

Cite this

Kasch, Richard ; Scheele, Josephin ; Hancock, Mark ; Hofer, André ; Maher, Christopher ; Bülow, Robin ; Lange, Jörn ; Lahm, Andreas ; Napp, Matthias ; Wassilew, Georgi ; Schmidt, Carsten Oliver. / Prevalence of benign osseous lesions of the spine and association with spinal pain in the general population in whole body MRI. In: PLoS ONE. 2019 ; Vol. 14, No. 9. pp. 1-15.
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title = "Prevalence of benign osseous lesions of the spine and association with spinal pain in the general population in whole body MRI",
abstract = "Background: Benign osseous lesions of the spine are common but precise population prevalence estimates are lacking. Our study aimed to provide the first population-based prevalence estimates and examine association with back and neck pain. Materials and methods: We used data from the population-based Study of Health in Pomerania (SHIP). Whole-body MRI examinations (1.5 Tesla: T1, T2, and TIRM weightings) were available from 3,259 participants. Readings of the spinal MRI images were conducted according to a standardized protocol by a single reader (JS). The intra-rater reliability was greater than Kappa values of 0.98. Pain measures included the seven-day prevalence of spine pain and neck pain, and average spine pain intensity due to spine pain during the past three months. Results: We found 1,200 (36.8{\%}) participants with at least one osseous lesion (2,080 lesions in total). Osseous lesions were less common in men than in women (35.5{\%} vs 38.9{\%}; P = .06). The prevalence of osseous lesions was highest at L2 in both sexes. The prevalence of osseous lesions increased with age. Up to eight osseous lesions were observed in a single subject. Hemangioma (28{\%}), and lipoma (13{\%}) occurred most often. Sclerosis (1.7{\%}), aneurysmal bone cysts (0.7{\%}), and blastoma (0.3{\%}) were rare. Different osseous lesions occurred more often in combination with each other. The association with back or neck pain was mostly negligible. Conclusion: Osseous lesions are common in the general population but of no clinical relevance for spinal pain. The prevalence of osseous lesions varied strongly across different regions of the spine and was also associated with age and gender. Our population-based data offer new insights and assist in judging the relevance of osseous lesions observed on MRIs of patients.",
author = "Richard Kasch and Josephin Scheele and Mark Hancock and Andr{\'e} Hofer and Christopher Maher and Robin B{\"u}low and J{\"o}rn Lange and Andreas Lahm and Matthias Napp and Georgi Wassilew and Schmidt, {Carsten Oliver}",
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Kasch, R, Scheele, J, Hancock, M, Hofer, A, Maher, C, Bülow, R, Lange, J, Lahm, A, Napp, M, Wassilew, G & Schmidt, CO 2019, 'Prevalence of benign osseous lesions of the spine and association with spinal pain in the general population in whole body MRI', PLoS ONE, vol. 14, no. 9, e0219846, pp. 1-15. https://doi.org/10.1371/journal.pone.0219846

Prevalence of benign osseous lesions of the spine and association with spinal pain in the general population in whole body MRI. / Kasch, Richard; Scheele, Josephin; Hancock, Mark; Hofer, André; Maher, Christopher; Bülow, Robin; Lange, Jörn; Lahm, Andreas; Napp, Matthias; Wassilew, Georgi; Schmidt, Carsten Oliver.

In: PLoS ONE, Vol. 14, No. 9, e0219846, 01.01.2019, p. 1-15.

Research output: Contribution to journalArticleResearchpeer-review

TY - JOUR

T1 - Prevalence of benign osseous lesions of the spine and association with spinal pain in the general population in whole body MRI

AU - Kasch, Richard

AU - Scheele, Josephin

AU - Hancock, Mark

AU - Hofer, André

AU - Maher, Christopher

AU - Bülow, Robin

AU - Lange, Jörn

AU - Lahm, Andreas

AU - Napp, Matthias

AU - Wassilew, Georgi

AU - Schmidt, Carsten Oliver

N1 - Copyright the Author(s) 2019. Version archived for private and non-commercial use with the permission of the author/s and according to publisher conditions. For further rights please contact the publisher.

PY - 2019/1/1

Y1 - 2019/1/1

N2 - Background: Benign osseous lesions of the spine are common but precise population prevalence estimates are lacking. Our study aimed to provide the first population-based prevalence estimates and examine association with back and neck pain. Materials and methods: We used data from the population-based Study of Health in Pomerania (SHIP). Whole-body MRI examinations (1.5 Tesla: T1, T2, and TIRM weightings) were available from 3,259 participants. Readings of the spinal MRI images were conducted according to a standardized protocol by a single reader (JS). The intra-rater reliability was greater than Kappa values of 0.98. Pain measures included the seven-day prevalence of spine pain and neck pain, and average spine pain intensity due to spine pain during the past three months. Results: We found 1,200 (36.8%) participants with at least one osseous lesion (2,080 lesions in total). Osseous lesions were less common in men than in women (35.5% vs 38.9%; P = .06). The prevalence of osseous lesions was highest at L2 in both sexes. The prevalence of osseous lesions increased with age. Up to eight osseous lesions were observed in a single subject. Hemangioma (28%), and lipoma (13%) occurred most often. Sclerosis (1.7%), aneurysmal bone cysts (0.7%), and blastoma (0.3%) were rare. Different osseous lesions occurred more often in combination with each other. The association with back or neck pain was mostly negligible. Conclusion: Osseous lesions are common in the general population but of no clinical relevance for spinal pain. The prevalence of osseous lesions varied strongly across different regions of the spine and was also associated with age and gender. Our population-based data offer new insights and assist in judging the relevance of osseous lesions observed on MRIs of patients.

AB - Background: Benign osseous lesions of the spine are common but precise population prevalence estimates are lacking. Our study aimed to provide the first population-based prevalence estimates and examine association with back and neck pain. Materials and methods: We used data from the population-based Study of Health in Pomerania (SHIP). Whole-body MRI examinations (1.5 Tesla: T1, T2, and TIRM weightings) were available from 3,259 participants. Readings of the spinal MRI images were conducted according to a standardized protocol by a single reader (JS). The intra-rater reliability was greater than Kappa values of 0.98. Pain measures included the seven-day prevalence of spine pain and neck pain, and average spine pain intensity due to spine pain during the past three months. Results: We found 1,200 (36.8%) participants with at least one osseous lesion (2,080 lesions in total). Osseous lesions were less common in men than in women (35.5% vs 38.9%; P = .06). The prevalence of osseous lesions was highest at L2 in both sexes. The prevalence of osseous lesions increased with age. Up to eight osseous lesions were observed in a single subject. Hemangioma (28%), and lipoma (13%) occurred most often. Sclerosis (1.7%), aneurysmal bone cysts (0.7%), and blastoma (0.3%) were rare. Different osseous lesions occurred more often in combination with each other. The association with back or neck pain was mostly negligible. Conclusion: Osseous lesions are common in the general population but of no clinical relevance for spinal pain. The prevalence of osseous lesions varied strongly across different regions of the spine and was also associated with age and gender. Our population-based data offer new insights and assist in judging the relevance of osseous lesions observed on MRIs of patients.

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DO - 10.1371/journal.pone.0219846

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