Primary breast cancer of the vulva: a case report and literature review

Loma Al-Mansouri, Pirooz Poursoltan, Mary Simons, Anita Muljono, John Boyages*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)

Abstract

An elderly lady presented with a 2-year history of intermittent vaginal bleeding and later the development of a vulvovaginal mass. A core biopsy histology specimen from the mass and the left inguinal lymph node was suggestive of metastatic adenocarcinoma of breast origin. No breast lesion was detected on mammography, and axillary nodes were negative. The histopathologic features and the expression of GATA3, cytokeratin (CK)7, mammaglobin staining and estrogen and progesterone receptors led to a diagnosis of breast cancer originating from the ectopic mammary tissue in the vulva. Given the rarity of these lesions, and the lack of standard treatment guidelines, the management of the patient was extrapolated from the established breast cancer treatment guidelines. Radiotherapy and chemotherapy followed by hormone therapy with aromatase inhibitor were administered to this patient in the metastatic setting with good palliation.

Original languageEnglish
Pages (from-to)2190-2194
Number of pages5
JournalJournal of Obstetrics and Gynaecology Research
Volume44
Issue number12
Early online date20 Aug 2018
DOIs
Publication statusPublished - Dec 2018

Keywords

  • breast cancer
  • carcinoma of the vulva
  • ectopic breast cancer

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