Primary breast cancer of the vulva: a case report and literature review

Loma Al-Mansouri, Pirooz Poursoltan, Mary Simons, Anita Muljono, John Boyages*

*Corresponding author for this work

    Research output: Contribution to journalArticlepeer-review

    3 Citations (Scopus)


    An elderly lady presented with a 2-year history of intermittent vaginal bleeding and later the development of a vulvovaginal mass. A core biopsy histology specimen from the mass and the left inguinal lymph node was suggestive of metastatic adenocarcinoma of breast origin. No breast lesion was detected on mammography, and axillary nodes were negative. The histopathologic features and the expression of GATA3, cytokeratin (CK)7, mammaglobin staining and estrogen and progesterone receptors led to a diagnosis of breast cancer originating from the ectopic mammary tissue in the vulva. Given the rarity of these lesions, and the lack of standard treatment guidelines, the management of the patient was extrapolated from the established breast cancer treatment guidelines. Radiotherapy and chemotherapy followed by hormone therapy with aromatase inhibitor were administered to this patient in the metastatic setting with good palliation.

    Original languageEnglish
    Pages (from-to)2190-2194
    Number of pages5
    JournalJournal of Obstetrics and Gynaecology Research
    Issue number12
    Early online date20 Aug 2018
    Publication statusPublished - Dec 2018


    • breast cancer
    • carcinoma of the vulva
    • ectopic breast cancer


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