Primary structure of a Plasmodium falciparum rhoptry antigen

Heidi J. Brown, Ross L. Coppel*

*Corresponding author for this work

Research output: Contribution to journalArticle

66 Citations (Scopus)

Abstract

The high-molecular-weight rhoptry complex of Plasmodium falciparum consists of 3 non-covalently associated polypeptides of 150, 135 and 105 kDa. We present the complete nucleotide sequence of the 105-kDa (RhopH3) component of this complex derived from analysis of genomic and cDNA clones. The genomic structure is unusually complex for P. falciparum, consisting of 7 exons including 2 mini-exons of 19 and 21 amino acids. The sequence lacks tandem repeats and is conserved among several parasite isolates. B cell epitopes that induce antibody responses during natural infection were mapped to five different regions of the polypeptide.

Original languageEnglish
Pages (from-to)99-110
Number of pages12
JournalMolecular and Biochemical Parasitology
Volume49
Issue number1
DOIs
Publication statusPublished - Nov 1991
Externally publishedYes

Keywords

  • Plasmodium falciparum
  • rhoptry antigen
  • intron
  • RhopH3

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