Abstract
The high-molecular-weight rhoptry complex of Plasmodium falciparum consists of 3 non-covalently associated polypeptides of 150, 135 and 105 kDa. We present the complete nucleotide sequence of the 105-kDa (RhopH3) component of this complex derived from analysis of genomic and cDNA clones. The genomic structure is unusually complex for P. falciparum, consisting of 7 exons including 2 mini-exons of 19 and 21 amino acids. The sequence lacks tandem repeats and is conserved among several parasite isolates. B cell epitopes that induce antibody responses during natural infection were mapped to five different regions of the polypeptide.
| Original language | English |
|---|---|
| Pages (from-to) | 99-110 |
| Number of pages | 12 |
| Journal | Molecular and Biochemical Parasitology |
| Volume | 49 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - Nov 1991 |
| Externally published | Yes |
Keywords
- Plasmodium falciparum
- rhoptry antigen
- intron
- RhopH3
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