Probing the Interior Crystal Quality in the Development of More Efficient and Smaller Upconversion Nanoparticles

Chenshuo Ma, Xiaoxue Xu*, Fan Wang, Zhiguang Zhou, Shihui Wen, Deming Liu, Jinghua Fang, Candace I. Lang, Dayong Jin

*Corresponding author for this work

Research output: Contribution to journalArticle

33 Citations (Scopus)

Abstract

Optical biomedical imaging using luminescent nanoparticles as contrast agents prefers small size, as they can be used at high dosages and efficiently cleared from body. Reducing nanoparticle size is critical for the stability and specificity for the fluorescence nanoparticles probes for in vitro diagnostics and subcellular imaging. The development of smaller and brighter upconversion nanoparticles (UCNPs) is accordingly a goal for complex imaging in bioenvironments. At present, however, small UCNPs are reported to exhibit less emission intensity due to increased surface deactivation and decreased number of dopants. Here we show that smaller and more efficient UCNPs can be made by improving the interior crystal quality via controlling heating rate during synthesis. We further developed a unique quantitative method for optical characterizations on the single UCNPs with varied sizes and the corresponding shell passivated UCNPs, confirming that the internal crystal quality dominates the relative emission efficiency of the UCNPs.

Original languageEnglish
Pages (from-to)3252-3258
Number of pages7
JournalJournal of Physical Chemistry Letters
Volume7
Issue number16
DOIs
Publication statusPublished - 18 Aug 2016

Fingerprint Dive into the research topics of 'Probing the Interior Crystal Quality in the Development of More Efficient and Smaller Upconversion Nanoparticles'. Together they form a unique fingerprint.

  • Cite this