Proflavine derivatives as fluorescent imaging agents of amyloid deposits

Dominique Garin, Fatima Oukhatar, Andrew B. Mahon, Andrew C. Try, Michel Dubois-Dauphin, Frank M. Laferla, Martine Demeunynck, Marcelle Moulin Sallanon, Sabine Chierici

Research output: Contribution to journalArticlepeer-review

8 Citations (Scopus)

Abstract

A series of proflavine derivatives for use to further image Aβ amyloid deposits were synthesized and characterized. Aged 3xTg-AD (23 months old) mice hippocampus sections incubated with these derivatives revealed preferential labeling of amyloid plaques. Furthermore an in vitro binding study showed an inhibitory effect, although moderate, of these compounds on Aβ40 fibril formation. This study highlights the potential of proflavine as a molecular scaffold for designing new Aβ imaging agents, its native fluorescence allowing in vitro neuropathological staining in AD damaged brain sections.

Original languageEnglish
Pages (from-to)2203-2206
Number of pages4
JournalBioorganic and Medicinal Chemistry Letters
Volume21
Issue number8
DOIs
Publication statusPublished - 15 Apr 2011

Keywords

  • proflavine
  • click chemistry
  • fluorescent markers
  • amyloid deposits imaging

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