Profound deafness in childhood

Andrej Kral*, Gerard M. O'Donoghue

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

217 Citations (Scopus)

Abstract

Profound childhood deafness is not just a sensory loss but has a lifelong effect on many levels of brain function. Many developments are transforming the management of profound deafness; these include universal neonatal screening, early intervention, and advances in diagnostic neuroaudiology, molecular biology, and integrative neuroscience. Cochlear implantation has transformed developmental outcomes, providing access to spoken language for the majority of children who receive implants early in life. Laboratory investigations have elaborated the neurobiologic processes that follow auditory deprivation, particularly a physiological uncoupling of the auditory system, resulting in degradation of its functional connectivity with key centers in the brain.

Original languageEnglish
Pages (from-to)1438-1450
Number of pages13
JournalNew England Journal of Medicine
Volume363
Issue number15
DOIs
Publication statusPublished - 7 Oct 2010
Externally publishedYes

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