Abstract
Profound childhood deafness is not just a sensory loss but has a lifelong effect on many levels of brain function. Many developments are transforming the management of profound deafness; these include universal neonatal screening, early intervention, and advances in diagnostic neuroaudiology, molecular biology, and integrative neuroscience. Cochlear implantation has transformed developmental outcomes, providing access to spoken language for the majority of children who receive implants early in life. Laboratory investigations have elaborated the neurobiologic processes that follow auditory deprivation, particularly a physiological uncoupling of the auditory system, resulting in degradation of its functional connectivity with key centers in the brain.
| Original language | English |
|---|---|
| Pages (from-to) | 1438-1450 |
| Number of pages | 13 |
| Journal | New England Journal of Medicine |
| Volume | 363 |
| Issue number | 15 |
| DOIs | |
| Publication status | Published - 7 Oct 2010 |
| Externally published | Yes |