TY - JOUR
T1 - Prognosis of chronic unexplained dyspepsia
T2 - a prospective study of potential predictor variables in patients with endoscopically diagnosed nonulcer dyspepsia
AU - Talley, N. J.
AU - McNeil, D.
AU - Hayden, A.
AU - Colreavy, C.
AU - Piper, D. W.
PY - 1987
Y1 - 1987
N2 - The aim of this study was to determine if there were predictors of the symptomatic course of patients with chronic unexplained (essential) dyspepsia. After endoscopic assessment, 111 patients with essential dyspepsia were followed up by telephone interview every second month. Data were gathered, for a mean of 17 mo per patient, on the number of days of upper abdominal pain (the response variable) each month. In the 6-mo period before entry to the study the following predetermined predictor variables were collected: demographic factors (age, sex, social grade), number of pain days in the 6 mo before diagnosis, environmental factors (analgesics, nonsalicylate nonsteroidal antiinflammatory drugs, alcohol, smoking, coffee, tea), length of dyspepsia history, and past history of peptic ulcer. Prospectively for each month of follow-up, the following additional variables were recorded: environmental factors, treatment, and development of gastroesophageal reflux symptoms. It was found that (a) patients with more pain before diagnosis were significantly more likely to have pain over the follow-up, and (b) the taking of medications for dyspepsia and development of gastroesophageal reflux were associated with more days of pain over the follow-up (all p < 0.001). Demographic and environmental factors, length of dyspepsia history, and a past history of ulcer were of no significant predictive value. There was a decrease in pain over the follow-up period (p = 0.002), but this effect was limited to the first two periods after endoscopic diagnosis.
AB - The aim of this study was to determine if there were predictors of the symptomatic course of patients with chronic unexplained (essential) dyspepsia. After endoscopic assessment, 111 patients with essential dyspepsia were followed up by telephone interview every second month. Data were gathered, for a mean of 17 mo per patient, on the number of days of upper abdominal pain (the response variable) each month. In the 6-mo period before entry to the study the following predetermined predictor variables were collected: demographic factors (age, sex, social grade), number of pain days in the 6 mo before diagnosis, environmental factors (analgesics, nonsalicylate nonsteroidal antiinflammatory drugs, alcohol, smoking, coffee, tea), length of dyspepsia history, and past history of peptic ulcer. Prospectively for each month of follow-up, the following additional variables were recorded: environmental factors, treatment, and development of gastroesophageal reflux symptoms. It was found that (a) patients with more pain before diagnosis were significantly more likely to have pain over the follow-up, and (b) the taking of medications for dyspepsia and development of gastroesophageal reflux were associated with more days of pain over the follow-up (all p < 0.001). Demographic and environmental factors, length of dyspepsia history, and a past history of ulcer were of no significant predictive value. There was a decrease in pain over the follow-up period (p = 0.002), but this effect was limited to the first two periods after endoscopic diagnosis.
UR - http://www.scopus.com/inward/record.url?scp=0023146532&partnerID=8YFLogxK
M3 - Article
C2 - 3556987
AN - SCOPUS:0023146532
VL - 92
SP - 1060
EP - 1066
JO - Gastroenterology
JF - Gastroenterology
SN - 0016-5085
IS - 4
ER -