Prognostic factors in the surgical treatment of patients with oral carcinoma

Rajan S. Patel, Jonathan R. Clark, Richard Dirven, Rebecca Wyten, Kan Gao, Christopher J. O'Brien

Research output: Contribution to journalReview articlepeer-review

53 Citations (Scopus)

Abstract

The aim of the study was to analyse the clinical outcome of patients treated surgically for oral carcinoma. A retrospective cohort study was undertaken of 356 patients with oral cavity cancer whose clinicopathological information had been collected prospectively onto a dedicated head and neck database. Disease recurrence and survival were assessed. Neck metastases occurred in 42% of patients. Tumour thickness (both 2 and 5 mm) predicted the presence of nodal metastases. Both pathological T stage (P < 0.001) and tumour thickness cut-off of 5 mm (P = 0.03) were independent predictors of disease-specific survival. With a median follow up of 41 months, overall survival at 5 years was 59% and disease-specific survival was 73%. Patients with thick tumours have a high risk of nodal metastases and this supports the liberal use of elective selective neck dissection in patients with clinically negative necks.

Original languageEnglish
Pages (from-to)19-22
Number of pages4
JournalANZ Journal of Surgery
Volume79
Issue number1-2
DOIs
Publication statusPublished - Jan 2009
Externally publishedYes

Keywords

  • Head and neck cancer
  • Oral carcinoma
  • Recurrence
  • Squamous cell carcinoma

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